Article

Matrix metalloproteinases: multifunctional contributors to tumor progression.

Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
Molecular Medicine Today 05/2000; 6(4):149-56. pp.149-56
Source: PubMed

ABSTRACT Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases. Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs were originally implicated in invasion and metastasis during cancer progression. However, recent work extends a role for MMPs during multiple stages of tumor progression to include other functions such as growth, angiogenesis and migration. Based on studies in animal models implicating MMP activity in cancer, synthetic MMP inhibitors are currently being tested in a clinical setting.

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Keywords

angiogenesis
 
animal models implicating MMP activity
 
matrix-degrading abilities
 
metastasis
 
MMPs
 
multiple stages
 
recent work
 
synthetic MMP inhibitors
 
tumors
 

L J McCawley