Recurrent anomalies of 6q25 in chondromyxoid fibroma.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.
Human Pathlogy (Impact Factor: 2.81). 04/2000; 31(3):306-11. DOI: 10.1016/S0046-8177(00)80243-9
Source: PubMed

ABSTRACT Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] has been proposed as a specific genetic marker for chondromyxoid fibroma. In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoid fibroma cases showed clonal abnormalities of chromosome 6 but at a breakpoint on the long arm (q25) distal to that described in the pericentric inversion. These findings suggest that several distinct breakpoints on chromosome 6 are nonrandomly involved in chondromyxoid fibroma.

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