Experimental muscle pain produces central modulation of proprioceptive signals arising from jaw muscle spindles

Department of Oral and Craniofacial Biological Sciences, University of Maryland Baltimore, School of Dentistry, Baltimore, MD 21201, USA.
Pain (Impact Factor: 5.21). 06/2000; 86(1-2):151-62. DOI: 10.1016/S0304-3959(00)00231-1
Source: PubMed

ABSTRACT The aim of the present study was to investigate the effects of intramuscular injection with hypertonic saline, a well-established experimental model for muscle pain, on central processing of proprioceptive input from jaw muscle spindle afferents. Fifty-seven cells were recorded from the medial edge of the subnucleus interpolaris (Vi) and the adjacent parvicellular reticular formation from 11 adult cats. These cells were characterized as central units receiving jaw muscle spindle input based on their responses to electrical stimulation of the masseter nerve, muscle palpation and jaw stretch. Forty-five cells, which were successfully tested with 5% hypertonic saline, were categorized as either dynamic-static (DS) (n=25) or static (S) (n=20) neurons based on their responses to different speeds and amplitudes of jaw movement. Seventy-six percent of the cells tested with an ipsilateral injection of hypertonic saline showed a significant modulation of mean firing rates (MFRs) during opening and/or holding phases. The most remarkable saline-induced change was a significant reduction of MFR during the hold phase in S units (100%, 18/18 modulated). Sixty-nine percent of the DS units (11/16 modulated) also showed significant changes in MFRs limited to the hold phase. However, in the DS neurons, the MFRs increased in seven units and decreased in four units. Finally, five DS neurons showed significant changes of MFRs during both opening and holding phases. Injections of isotonic saline into the ipsilateral masseter muscle had little effect, but hypertonic saline injections made into the contralateral masseter muscle produced similar results to ipsilateral injections with hypertonic saline. These results unequivocally demonstrate that intramuscular injection with an algesic substance, sufficient to produce muscle pain, produces significant changes in the proprioceptive properties of the jaw movement-related neurons. Potential mechanisms involved in saline-induced changes in the proprioceptive signals and functional implications of the changes are discussed.

8 Reads
  • Source
    • "Matre et al. (1998) suggested that experimental muscle pain may inhibit muscle spindle activity, and thereby proprioception . Other authors suggested that muscle nociceptive input decreased information provided by the brainstem neurons (Capra and Ro, 2000). Proprioception may be influenced by stretch evoked muscle reflexes. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Shoulder injuries may be associated with proprioceptive deficits, however, it is unknown whether these changes are due to the experience of pain, tissue damage, or a combination of these. The aim of this study was to investigate the effect of experimentally-induced sub-acromial pain on proprioceptive variables. Sub-acromial pain was induced via hypertonic saline injection in 20 healthy participants. Passive joint replication (PJR) and threshold to detection of movement direction (TTDMD) were assessed with a Biodex System 3 Pro isokinetic dynamometer for baseline control, experimental pain and recovery control conditions with a starting position of 60° shoulder abduction. The target angle for PJR was 60° external rotation, starting from 40°. TTDMD was tested from a position of 20° external rotation. Repeated measures ANOVAs were used to determine differences between PJR absolute and variable errors and TTDMD for the control and experimental conditions. Pain was elicited with a median 7 on the Numeric Pain Rating Scale. TTDMD was significantly decreased for the experimental pain condition compared to baseline and recovery conditions (≈30%, P = 0.003). No significant differences were found for absolute (P = 0.152) and variable (P = 0.514) error for PJR. Movement sense was enhanced for the experimental sub-acromial pain condition, which may reflect protective effects of the central nervous system in response to the pain. Where decreased passive proprioception is observed in shoulders with injuries, these may be due to a combination of peripheral tissue injury and neural adaptations that differ from those due to acute pain.
    Manual Therapy 09/2014; 20(1). DOI:10.1016/j.math.2014.08.009 · 1.71 Impact Factor
  • Source
    • "al, pain causes presynaptic inhibition of muscle afferents [8]. Carpa and Ro showed that pain in the masticatory muscles can alter the central modulation, which in turn, influences the proprioceptive muscle spindles [9]. These muscular inhibition mechanisms due to pain might have a negative effect on balance ability. "
    [Show abstract] [Hide abstract]
    ABSTRACT: In therapeutic settings, patients with shoulder pain often exhibit deficient coordinative abilities in their trunk and lower extremities. The aim of the study was to investigate 1) if there is a connection between shoulder pain and deficits in balance ability and postural stability, 2) if pain intensity is related to balance ability and postural stability, and 3) if there is a connection between body mass index (BMI) and balance ability and postural stability. In this case--control study, patients (n = 40) with pathological shoulder pain (> 4 months) were matched with a healthy controls (n = 40) and were compared with regard to their balance ability and postural stability. Outcome parameters were postural stability, balance ability and symmetry index which were measured using the S3-Check system. In addition, the influence of shoulder pain intensity and BMI on the outcome parameters was analysed. Patients with shoulder pain showed significantly worse results in measurements of postural stability right/left (p < 0.01) and front/back (p < 0.01) as well as balance ability right/left (p = 0.01) and front/back (p < 0.01) compared to healthy controls. There were no significant group differences with regard to symmetry index. However, there was a significant (p < 0.01) symmetry shift towards the affected side within the shoulder pain group. There was no correlation between pain intensity and measurements of balance ability or postural stability. Likewise, no correlation between BMI and deficiencies in balance ability and postural stability was established. Patients with pathological shoulder pain (> 4 months) have deficiencies in balance ability and postural stability; however the underlying mechanisms for this remain unclear. Neither pain intensity nor BMI influenced the outcome parameters. Patients with shoulder pain shift their weight to the affected side. Further research is needed to determine if balance training can improve rehabilitation results in patients with shoulder pathologies.
    BMC Musculoskeletal Disorders 10/2013; 14(1):282. DOI:10.1186/1471-2474-14-282 · 1.72 Impact Factor
  • Source
    • "As seen in the latter stage, there is tendency of reduced variability, i.e. decreased VE between 'after I' and 'after II', injected side (p = 0.050; Table 4) with increasing changes of TAR E (successive increases in the univariate analysis for tar30° E , injected and non-injected side combined, Fig. 2a). Earlier studies have reported movement control changes (Ervilha et al. 2004b; Falla et al. 2007; Farina et al. 2005; Hodges et al. 2003; Madeleine et al. 1999), as well as central modulation in experimental pain states (Capra and Ro 2000; Farina et al. 2005; Korotkov et al. 2002; Masri et al. 2005). With the knowledge that there is a harmonized activation of different muscular layers (Blouin et al. 2007), one "
    [Show abstract] [Hide abstract]
    ABSTRACT: We wanted to explore the specific proprioceptive effect of cervical pain on sensorimotor control. Sensorimotor control comprises proprioceptive feedback, central integration and subsequent muscular response. Pain might be one cause of previously reported disturbances in joint kinematics, head on trunk orientation and postural control. However, the causal relationship between the impact of cervical pain on proprioception and thus on sensorimotor control has to be established. Eleven healthy subjects were examined in their ability to reproduce two different head on trunk targets, neutral head position (NHP) and 30° target position, with a 3D motion analyser before, directly after and 15 min after experimentally induced neck pain. Pain was induced by hypertonic saline infusion at C2/3 level in the splenius capitis muscle on one side (referred to as "injected side"). All subjects experienced temporary pain and the head repositioning error increased significantly during head repositioning to the 30° target to the injected side (p = 0.011). A post hoc analysis showed that pain interfered with proprioception to the injected side during acute pain (p < 0.001), but also when the pain had waned (p = 0.002). Accuracy decreased immediately after pain induction for the 30° target position to the side where pain was induced (3.3 → 5.3°, p = 0.033), but not to the contralateral side (4.9 → 4.1°, p = 0.657). There was no significant impact of pain on accuracy for NHP. A sensory mismatch appeared in some subjects, who experienced dizziness. Acute cervical pain distorts sensorimotor control with side-specific changes, but also has more complex effects that appear when pain has waned.
    Arbeitsphysiologie 06/2013; 113(10). DOI:10.1007/s00421-013-2683-y · 2.19 Impact Factor
Show more