Article

Reduced olfactory bulb volume in patients with schizophrenia.

Department of Psychiatry, Radiology, and Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA 19104, USA.
American Journal of Psychiatry (impact factor: 12.54). 06/2000; 157(5):828-30. pp.828-30
Source: PubMed

ABSTRACT The authors' goal in this study was to compare the size of olfactory bulbs of patients with schizophrenia and those of healthy subjects.
Magnetic resonance imaging scans of olfactory bulbs were obtained from 26 patients with schizophrenia and 22 healthy comparison subjects. A reliable region of interest procedure was used to measure olfactory bulb volume.
Patients exhibited 23% smaller bilateral bulb volume than comparison subjects, independent of acute clinical, demographic, or treatment measures. Bulb volume correlated with odor detection sensitivity in healthy subjects but not in patients with schizophrenia.
Patients with schizophrenia exhibit structural olfactory deficits as well as functional olfactory deficits. The olfactory system may be a model system in which to study the neurobiology of the disorder.

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Keywords

22 healthy comparison subjects
 
26 patients
 
authors' goal
 
Bulb volume correlated
 
comparison subjects
 
functional olfactory deficits
 
healthy subjects
 
independent
 
Magnetic resonance imaging scans
 
measure olfactory bulb volume
 
model system
 
olfactory bulbs
 
patients
 
Patients exhibited 23% smaller bilateral bulb volume
 
reliable region
 
schizophrenia exhibit structural olfactory deficits
 
treatment measures