[Cyclosporin in an oral microemulsion as the initial treatment of corticoid-refractory ulcerative colitis].
ABSTRACT To assess the efficacy of oral microemulsion cyclosporin as the initial treatment of active ulcerative colitis refractory to steroid therapy.
The evolution of five patients treated with a dose of 5 mg/kg/day was analyzed.
Oral microemulsion cyclosporin controlled acute attacks of the disease and led to remission during the 3 months of treatment in four of the five patients. Average hospital stay was 5.5 days.
Oral microemulsion cyclosporin is an effective treatment in ulcerative colitis. Its administration is simple, the use of venous catheters is avoided and it may reduce mean hospital stay.
- [show abstract] [hide abstract]
ABSTRACT: Immunosuppressive drugs are the backbone of solid organ transplantation. The introduction of new immunosuppressive drugs led to improved patient and organ survival rates. Nowadays, acute rejection can be reduced to a minimum. Individualization and avoidance of drug-related adverse effects became a new goal to achieve. The potency of immunosuppressive drugs makes them attractive for use in various autoimmune diseases; therefore, the experience on immunosuppressive drugs outside the field of organ transplantation is analysed in this review.Expert Opinion on Investigational Drugs 04/2006; 15(3):267-91. · 4.74 Impact Factor
- The Israel Medical Association journal: IMAJ 09/2000; 2(8):607-9. · 0.98 Impact Factor