Placebo-Controlled Study of Fluvoxamine in the Treatment of Patients With Compulsive Buying

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.
Journal of Clinical Psychopharmacology (Impact Factor: 3.24). 07/2000; 20(3):362-6. DOI: 10.1097/00004714-200006000-00012
Source: PubMed

ABSTRACT Compulsive buying is a syndrome characterized by the impulsive and/or compulsive buying of unneeded objects that results in personal distress, impairment in vocational or social functioning, and/or financial problems. Results from a two-site, double-blind, placebo-controlled 13-week trial of fluvoxamine are presented. Subjects had problematic buying behavior that they could not control for the previous 6 months or longer and met DSM-IV criteria for impulse control disorder-not otherwise specified (ICD-NOS) and the University of Cincinnati criteria for compulsive buying. Assessments included clinician-rated scales-the Yale-Brown Obsessive Compulsive Scale modified for compulsive buying, the Clinical Global Impression Scale, the Global Assessment of Functioning, and the Hamilton Rating Scale for Depression-and patient self-reports using daily diaries, which measured episodes of compulsive buying. Forty-two subjects gave informed consent, with 37 subjects providing evaluable information and 23 completing the study. Current or past psychiatric comorbidity was present in 74% of subjects. Intent-to-treat and completer analyses failed to show a significant difference between treatments on any measures of outcome. A high placebo-response rate, possibly from the behavioral benefits of maintaining a daily diary, prevents any definitive statement on the efficacy of fluvoxamine in treating compulsive buying.

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Available from: Charles B Nemeroff, Sep 26, 2015
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    • "People with CBD in this pilot study were similar demographically and clinically to those described by other investigators, and their disorder was of moderate severity (Christenson et al., 1994; McElroy et al., 1994; Ninan et al., 2000; Miltenberger et al., 2003; Koran et al., 2003, 2007). In short, CBD was primarily a disorder of middle-aged women who had struggled with the condition for nearly 17 years. "
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    ABSTRACT: We examined the neuropsychological performance of people with compulsive buying disorder (CBD) and control subjects, along with trait impulsivity, symptoms of attention deficit hyperactivity disorder (ADHD), and selected personality characteristics. Subjects received a comprehensive neuropsychological test battery, depression and ADHD symptom assessment, the Barratt Impulsiveness Scale, and a version of the Temperament and Character Inventory. Persons with CBD (n=26) and controls (n=32) were comparable in terms of age, sex, and years of education. Subjects with CBD had a mean age of 36.3 years (S.D.=15.7) and an age at onset of 19.7 years (S.D.=7.0). Compulsive buyers had more lifetime mood, anxiety, and impulse control disorders. People with Compulsive buying performed significantly better on the Wechsler Abbreviated Scale of Intelligence Picture Completion task, a test of visual perception; otherwise, there were no consistent differences in neuropsychological measures. They also had elevated levels of self-reported depression, ADHD symptoms, trait impulsivity, and novelty seeking. In conclusion, compulsive buyers have greater lifetime psychiatric comorbidity than controls, and higher levels of self-rated depression, ADHD symptoms, trait impulsivity, and novelty seeking. The present study does not support the notion that there is a pattern of neuropsychological deficits associated with CBD.
    Psychiatry Research 07/2012; 200(2-3). DOI:10.1016/j.psychres.2012.06.003 · 2.47 Impact Factor
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    • "In one study, 37 CB subjects were treated with fluvoxamine for 13 weeks. Both the fluvoxamine and placebo groups significantly improved from baseline on measures of CB thoughts/urges and behaviors (Ninan et al., 2000a). Similar results were found by Black et al. (2000) who found no difference in response rates when comparing fluvoxamine to placebo in 23 participants treated for 9 weeks. "
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    ABSTRACT: Impulse control disorders (ICDs) are characterized by urges and behaviors that are excessive and/or harmful to oneself or others and cause significant impairment in social and occupational functioning, as well as legal and financial difficulties. ICDs are relatively common psychiatric conditions, yet are poorly understood by the general public, clinicians, and individuals struggling with the disorder. Although ICD treatment research is limited, studies have shown ICDs may respond well to pharmacological treatment. This article presents a brief overview about the clinical characteristics of ICDs and pharmacological treatment options for individuals with ICDs.
    Frontiers in Psychiatry 02/2011; 2(10):1. DOI:10.3389/fpsyt.2011.00001
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    • "Researchers have offered various definitions of compulsive buying: " chronic repetitive purchasing " (O'Guinn and Faber 1989, 155); " impulsive and/or compulsive buying of unneeded objects " (Ninan et al. 2000, 362); and " excessive or poorly controlled preoccupations, urges or behaviors regarding . . . spending " (Black 2001, 17). "
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    ABSTRACT: Drawing on the theoretical foundation of obsessive-compulsive spectrum disorder, this article develops an expanded conceptualization and new measure of consumers' proclivity to buy compulsively. Compulsive buying is defined as a consumer's tendency to be preoccupied with buying that is revealed through repetitive buying and a lack of impulse control over buying. This measure includes dimensions of both obsessive-compulsive and impulse-control disorders. By measuring income-dependent items or consequences of compulsive buying separately from the compulsive-buying scale, we develop a measure that has a strong theoretical foundation, well-documented psychometric properties, and an ability to be applied to general consumer populations. (c) 2008 by JOURNAL OF CONSUMER RESEARCH, Inc..
    Journal of Consumer Research 12/2008; 35(4):622-639. DOI:10.1086/591108 · 3.10 Impact Factor
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