Single-molecule studies of DNA mechanics.

Department of Molecular and Cell Biology, Department of Physics, University of California, Berkeley, CA 94720, USA. carlos@alice.
Current Opinion in Structural Biology (Impact Factor: 8.75). 07/2000; 10(3):279-85. DOI: 10.1016/S0959-440X(00)00085-3
Source: PubMed

ABSTRACT During the past decade, physical techniques such as optical tweezers and atomic force microscopy were used to study the mechanical properties of DNA at the single-molecule level. Knowledge of DNA's stretching and twisting properties now permits these single-molecule techniques to be used in the study of biological processes such as DNA replication and transcription.

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