The effects of the mycotoxin fumonisin B(1) (FB(1)) on the hepatic cytochrome P450 system were investigated in male rats dosed daily by oral gavage with 3 mg FB(1) per kg body weight for 9 consecutive days. FB(1) treatment resulted in a reduced weight gain. At the same time, CYP2E activity was increased, which is considered to mark the metabolic changes inherent to growth retardation in young rats. Treatment with FB(1) also resulted in a selective inhibition of CYP2C11 and to a lesser extent, CYP1A2 in liver microsomes obtained from treated animals, whereas it did not affect significantly the activity of CYP2A1/2A2, CYP2B1/2B2, CYP3A1/3A2 and CYP4A. The significant inhibition of CYP2C11 is considered to reflect a suppressed activity of protein kinase activity resulting from the inhibition of sphingolipid biosynthesis caused by FB(1).
"These proteins are vital for maintaining the membrane structure, cells communications , cells interactions, cell morphology, extracellular interactions (such as cell-matrix and cell–cell adhesion) and cell differentiation, adjusting of growth factors, carcinogenicity and apoptosis. Also, sphingolipids act as the secondary messenger in signal transduction pathways (Galvanoa et al., 2002; Kpodoa et al., 2000; Spotti et al., 2000; Turner et al., 1999; Voss et al., 2007; Warfield & Gilchrist, 1999). 96 F. Ahangarkani et al. "
"In the literature, there are only a few conflicting reports that have studied the effects of FB1 on Cyp activity (Martínez-Larrañaga et al., 1996; Spotti et al., 2000). Of these, our results are similar to those obtained by Martínez-Larrañaga et al. (1996), who reported an increase of Cyp1A activity in the liver of Wistar rats exposed to FB1. "
[Show abstract][Hide abstract] ABSTRACT: Alterations in the membrane structure and function of hepatocyte membranes by fumonisin B1 (FB1) have been proposed to play an important role in the disruption of growth regulatory effects and hence in the cancer-promoting
ability of the mycotoxin. Detailed analyses of lipids in liver microsomal fractions of rats exposed to different dietary levels
of FB1 over a period of 21 d indicated an increase in PC, PE, PI, and cholesterol (Chol). These changes decreased the PC/PE and
increased the total phospholipid/Chol ratios. When considering FA content, the quantities of total FA increased (P
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