Hepatitis C infection and associated oral health problems

Faculty of Dentistry, University of Adelaide.
Australian Dental Journal (Impact Factor: 1.48). 07/2000; 45(2):108-14. DOI: 10.1111/j.1834-7819.2000.tb00249.x
Source: PubMed

ABSTRACT Hepatitis C infection is widespread throughout the community. This study aimed to assess the status of oral health of persons infected with hepatitis C. DMFT and CPITN indices were recorded at a clinic providing priority dental care for people with hepatitis C infection. The data were compared with information from an existing survey of general dental patients. Social impact was assessed using a modified Oral Health Impact Profile questionnaire. The DMFT index differed significantly between hepatitis C and general patients. The number of decayed and missing teeth was greater in those infected with hepatitis C for all patients aged between 25 and 50 years. Although there was no significant difference in CPITN categories for subjects evaluated, a marked trend for poor periodontal health was noted for those individuals with hepatitis C. Salivary flow was reduced in 50 per cent of hepatitis C infected subjects. Social impact was significantly affected with 71 per cent of hepatitis C subjects reporting painful aching in the mouth and 56 per cent having difficulty in relaxing. In conclusion, the results from the project strongly indicate an urgent need for priority delivery of dental care for people with hepatitis C infection.

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Available from: Richard M Logan, Aug 12, 2015
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    • "However, $38% of HCV positive patients do not have a history of parenteral exposure. Some studies have reported finding HCV in saliva and the possible transmission of hepatitis C by this route [Chen et al., 1995; Coates et al., 2000; De Cock et al., 2004] "
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    ABSTRACT: Hepatitis C is a worldwide public health problem and its transmission is clearly associated with the parenteral route, however, the virus has also been isolated from other body fluids. Hepatitis C virus (HCV) RNA has been detected in saliva, yet the relationship between HCV and oral pathology is not clearly understood. Therefore, an investigation on HCV-RNA in saliva and its correlation with oral pathology was undertaken. Saliva and blood samples were collected from 50 anti-HCV positive patients and from 25 patients with non-HCV chronic liver disease. HCV-RNA was detected in all of the saliva samples from the HCV positive group. None of the saliva or serum samples from the non-HCV group were positive for HCV-RNA. The patients were examined for dental and oral health (dentate, partially dentate, edentulous, evidence of gum disease, or mucosal lesions); however, no correlation was found between HCV-RNA in saliva, oral health, and viral load. These results suggest that HCV-RNA presence in saliva is independent of the viral load and the oral pathology of HCV positive individuals.
    Journal of Medical Virology 11/2005; 77(2):216-20. DOI:10.1002/jmv.20438 · 2.22 Impact Factor
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    • "Curiously, a smallscale study from Egypt, which has the highest reported prevalence of HCV infection in the general population, did not report a significant association between LP and HCV (Ibrahim et al., 1999). The few studies investigating the frequency of LP among HVC-positive subjects showed that from 1.6 to 20% of patients with HCV-related chronic hepatic disease may have LP (Pawlotsky et al., 1994a; Dupin et al., 1997; Grote et al., 1998; Coates et al., 2000; Nagao et al., 2000b, 2002; Henderson et al., 2001; Mignogna et al., 2001). Because these prevalences are generally higher than expected, OLP would probably be more easily identified in HCV-infected patients in countries with low levels of HCV, such as the UK (Carrozzo, 2001). "
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    ABSTRACT: Morbidity associated with hepatitis C virus (HCV) infection can involve a variety of extrahepatic conditions, including lichen planus (LP) and sialadenitis, predominantly or exclusively involving the oral region, conditions which have been largely neglected in reviews. The literature suggests that HCV-infected patients may frequently have Sjögren-like sialadenitis with mild clinical symptoms, whereas oral LP may be significantly associated with HCV infections in Southern Europe and Japan but not in Northern Europe. These geographical differences could be related to immunogenetic factors such as the HLA-DR6 allele, significantly expressed in Italian patients with OLP and HCV. Analysis of experimental data suggests that HCV could be involved in the pathogenesis of both these diseases. Moreover, parotid lymphoma may arise in patients with sialadenitis, mainly with type II cryoglobulinemia. Little attention has been paid to oral health needs in HCV-infected patients and the variable effect of interferon-alpha therapy on oral tissues. Further research is needed, because of the potentially great influence of oral diseases possibly linked to HCV on the quality of life of millions of patients.
    Critical reviews in oral biology and medicine: an official publication of the American Association of Oral Biologists 02/2003; 14(2):115-27. DOI:10.1177/154411130301400205
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