Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure

London Health Sciences Centre, London, Canada.
European Heart Journal (Impact Factor: 15.2). 08/2000; 21(16):1368-75. DOI: 10.1053/euhj.1999.2043
Source: PubMed


In addition to diabetes mellitus, less severe abnormalities of glucose and insulin metabolism may be related to functional status in patients with heart failure. We examined the relationship of hyperglycaemia (> or =6.1 mmol. l(-1)) and hyperinsulinaemia (> or =11.2 mU. l(-1)) to functional status and cardiac function in patients with heart failure.
Fasting plasma glucose and insulin levels were obtained in 663 heart failure patients. The average left ventricular ejection fraction was 0.28+/-0.07, 63% were in New York Heart Association Functional Class (NYHA-FC) I/II and 37% were in NYHA-FC III/IV. Twenty seven percent had diabetes mellitus, but an additional 8% had undiagnosed diabetes mellitus (glucose > or =7 mmol. l(-1)) and 9% had glucose levels between 6.1 and 7 mmol. l(-1), so that a total of 43% (287) of patients had elevated glucose levels (> or =6.1 mmol. l(-1)). In general, more diabetic patients had NYHA-FC III/IV symptoms, shorter 6 min walk distances, but similar left ventricular ejection fractions compared to non-diabetic patients. The non-diabetic patients in NYHA-FC III/IV had higher glucose and insulin levels than patients in NYHA-FC I/II (6.3+/-0.2 vs 5.6+/-0.1 mmol. l(-1), P<0.001 and 19.6+/-2.3 vs 10. 2+/-0.6 mU. l(-1), P<0.001). Non-diabetic patients with elevated glucose levels had shorter 6 min walk distances compared to those with normal glucose levels (368.2+/-8 m vs 389.+/-4 m, P=0.02), however, left ventricular ejection fraction was similar.
Glucose abnormalities are extremely common in heart failure patients (43% of patients). Diabetes mellitus and hyperglycaemia or hyperlinsulinaemia in non-diabetic patients were related to worse symptomatic status but not worsening left ventricular ejection fraction compared to patients with normal glucose and insulin levels.

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Available from: Roberto Latini, Sep 01, 2014
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    • "Vitamin D also plays a key role in muscle contraction [12] and has been related to muscle pain and weakness, fatigue, and performance, derangements that can be reversed by its oral supplementation [13]. Diabetes, especially when poorly controlled and of long-standing duration, can cause myopathy [14], which, if associated with vitamin D deficiency and heart failure, can determine major muscle impairment, with consequent low physical function and strength [15] [16]. These interactions could contribute to low levels of physical activity usually seen in individuals with diabetes [17] and heart failure [18]. "
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