Article

Mild ciguatera poisoning: Case reports with neurophysiological evaluations.

Toxicology Unit, IRCCS Maugeri Foundation Medical Center, Via Ferrata, 8, 27100 Pavia, Italy.
Muscle & Nerve (impact factor: 2.37). 11/2000; 23(10):1598-603. pp.1598-603
Source: PubMed

ABSTRACT Ciguatera poisoning causes mainly gastrointestinal and neurological effects of variable severity. However, symptoms of peripheral neuropathy with paresthesias and paradoxical disturbance of thermal sensation are the hallmark. Electrophysiological studies are often normal, except in severe cases. We report four people who developed mild ciguatera poisoning after barracuda ingestion. Electrophysiological studies documented normocalcemic latent tetany. These findings are consistent with ciguatoxin's mechanism of toxicity, which involves inactivation of voltage-gated Na(+) channels and eventually increases nerve membrane excitability.

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Keywords

barracuda ingestion
 
increases nerve membrane excitability
 
involves inactivation
 
paresthesias
 
severe cases
 
thermal sensation
 
variable severity
 
voltage-gated Na(+)