Intravenous Valproate Treatment of Severe Manic Symptoms After Gastric Bypass Surgery: A Case Report

Psychosomatics (Impact Factor: 1.86). 09/2000; 41(5):454-6. DOI: 10.1176/appi.psy.41.5.454
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Available from: Ovidio De Leon, Jan 07, 2015
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    ABSTRACT: Over the last few years, the use of valproate in psychiatry has increased considerably. With the advent of oral loading dose strategy, its role in rapid treatment of acute mania has been demonstrated. The intravenous formulation of valproate, while retaining the rapidity of action of oral loading, also avoids some of the adverse effects of the oral preparation. Moreover, reports are pouring in that intravenous valproate loading may be more efficacious than oral valproate loading in the treatment of acute mania. We report two patients whose manic symptoms showed a dramatic response to intravenous valproate without adverse effects. The pharmacology of intravenous valproate and its clinical relevance to psychiatry are discussed.
    Indian Journal of Psychiatry 04/2002; 44(2):173-6.
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    ABSTRACT: This open-label study investigated whether acute antimanic effects and safety of intravenous valproate loading therapy is superior to oral valproate loading. Eighteen patients with DSM-IV diagnosis of either bipolar affective disorder or schizomania who met the study criteria were recruited (9 in the intravenous and 9 in the oral valproate group). Psychopathology was assessed with the scale for manic and mixed states on days 0 and 4. A checklist was used for the assessment of side effects. The results showed about 36% reduction in total mean manic scores with intravenous valproate loading; however, statistically, the degree of reduction in manic scores was comparable between the groups. A nonsignificant increase in the rate of adverse events was noted in the intravenous group. Despite its limitations, this study suggests that acute antimanic effects of both intravenous and oral valproate loading are comparable.
    Neuropsychobiology 02/2003; 47(2):90-3. DOI:10.1159/000070015 · 2.26 Impact Factor
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    ABSTRACT: This study evaluated the efficacy and tolerability of intravenous valproate in acute mania in adolescents. Five consecutive patients, meeting the study criteria, were treated with intravenous valproate. Of them, three significantly improved and one had no appreciable improvement. Two out of five patients experienced gastrointestinal and neurological side effects. This preliminary study suggests intravenous valproate is useful and safe to treat acute juvenile mania.
    European Child & Adolescent Psychiatry 09/2004; 13(4):258-61. DOI:10.1007/s00787-004-0360-8 · 3.34 Impact Factor
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