Minimum estimated incidence in Japan of anaphylaxis to live virus vaccines including gelatin

Department of Immunology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162, Japan.
Vaccine (Impact Factor: 3.62). 11/2000; 19(4-5):431-6. DOI: 10.1016/S0264-410X(00)00206-1
Source: PubMed

ABSTRACT We have previously found that most occurrences of anaphylaxis to live virus vaccines are caused by gelatin present in the vaccines as a stabilizer. After we published the evidence for the role of gelatin in anaphylaxis, vaccine manufacturers in Japan began to eliminate gelatin from live virus vaccines. In the present study, we tried to estimate its incidence before the gelatin elimination was started. Physicians and vaccine manufacturers submitted serum samples from children with anaphylaxis to measles, mumps, rubella or varicella vaccine to National Institute of Infectious Diseases (NIID) for 3 years from April 1994 to March 1997. Specific IgE to gelatin was assayed at NIID or two manufacturers by the CAP and ELISA methods. There were 44 children with life-threatening severe anaphylaxis (airway obstruction or anaphylactic shock) during the 3-year period, 41 of whom had anti-gelatin IgE. There were 64 children with mild anaphylaxis (without airway obstruction); 62 had anti-gelatin IgE. There were 100 children with only systemic cutaneous signs; 81 had anti-gelatin IgE. The estimates for the incidence of the severe anaphylaxis in 1994-1996 are: 6.84, 7.31, 4. 36, and 10.3 cases per million doses of gelatin-containing measles, rubella, mumps, and varicella vaccines, respectively.

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    • "The questionnaire was distributed by the Japan Small Animal Veterinary Association to veterinary hospitals in Japan from April 1, 2006 through May 31, 2007. et al., 1995; Roth, 1999) occasionally observed in humans and dogs after vaccination, and which sometimes causes death (Brooks, 1991; Sakaguchi et al., 2000). According to large epidemiological studies on canine VAAEs, the incidences of anaphylaxis were 0.018/10,000 vaccinated dogs in the United Kingdom (Gaskell et al., 2002) and 0.65/10,000 vaccinated dogs in the United States (Moore et al., 2005). "
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    ABSTRACT: Keywords:adverse reaction;anaphylaxis;gelatin;IgE;Japanese encephalitis vaccine
    Allergy 09/2001; 56(8):804-5. DOI:10.1034/j.1398-9995.2001.056008804.x · 6.03 Impact Factor
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    ABSTRACT: Systemic immediate reactions including anaphylaxis to gelatin in vaccines have been reported. However, the number of such reports is very small compared with the number of children exposed to gelatin. The present study was designed to investigate whether susceptibility or resistance to gelatin allergy is associated with human leukocyte antigen (HLA) class II gene. Blood samples were obtained from 49 patients with gelatin allergy and specific IgE to gelatin. DNA-based HLA class II typing was performed to determine the DRB1, DQB1 and DPB1 alleles. Genotype frequencies were compared with those found in 240 unrelated controls. The frequency of DQB1*0303 (55.1%) was significantly higher in the patients than in the control subjects (32.1%). The frequency of DPB1*0402 was also significantly higher in the patients (32.7%) than in the control subjects (15.4%). On the other hand, the frequency of subjects carrying DRB1*15 (DRB1*1501 and DRB1*1502) was significantly lower among the patients group (18.4%) than among the controls (40.8%). We found that DQB1*0303 and DPB1*0402 were positively associated with the IgE response for gelatin, while DRB1*15 was negatively associated with it.
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