Hepatocellular carcinoma and non-Hodgkin lymphoma in a patient with chronic hepatitis C and cirrhosis.
ABSTRACT Hepatitis C virus (HCV) is a hepatotropic virus, but its genome and replicative intermediates also have been detected in peripheral blood mononuclear cells in patients with chronic hepatitis C. Chronic HCV infection may lead to hepatocellular carcinoma and, in a small percentage of cases, to B-cell non-Hodgkin lymphoma. To our knowledge, coexistence of these 2 tumors has not been reported previously. We describe a case of chronic hepatitis C and cirrhosis with 2 small hepatocellular carcinomas and incidental non-Hodgkin lymphoma of a hilar lymph node found during liver transplantation. Although the mechanisms of HCV oncogenesis in hepatocellular carcinoma and in lymphoma are unclear, the presence of these 2 tumors in a single patient are in agreement with the tropism of HCV and its role in oncogenesis.
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ABSTRACT: We report a case of repeat hepatectomies for hepatic malignant lymphoma and hepatocellular carcinoma (HCC). A 75-year-old man with chronic hepatitis C underwent partial hepatectomy for a 25 mm hepatic tumor in S5. The histological diagnosis was diffuse large B-cell malignant lymphoma and as postoperative (18)F-fluorodeoxyglucose-positron emission tomography showed no hot spots, the mass was presumed to be primary hepatic lymphoma. Thus, adjuvant systemic chemotherapy was given following the hepatectomy. Abdominal ultrasonography, done 12 months after the hepatectomy, showed a hepatic tumor in S6 and repeat partial hepatectomy was performed. This tumor was histologically diagnosed as HCC.Surgery Today 02/2013; 44(1). DOI:10.1007/s00595-013-0502-z · 1.21 Impact Factor
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ABSTRACT: Cirrhosis and hepatocellular carcinoma are the prototypic complications of chronic hepatitis C virus infection in the liver. However, hepatitis C virus also affects a variety of other organs that may lead to significant morbidity and mortality. Extrahepatic manifestations of hepatitis C infection include a multitude of disease processes affecting the small vessels, skin, kidneys, salivary gland, eyes, thyroid, and immunologic system. The majority of these conditions are thought to be immune mediated. The most documented of these entities is mixed cryoglobulinemia. Morphologically, immune complex depositions can be identified in small vessels and glomerular capillary walls, leading to leukoclastic vasculitis in the skin and membranoproliferative glomerulonephritis in the kidney. Other HCV-associated entities include porphyria cutanea tarda, lichen planus, necrolytic acral erythema, membranous glomerulonephritis, diabetic nephropathy, B-cell non-Hodgkin lymphomas, insulin resistance, sialadenitis, sicca syndrome, and autoimmune thyroiditis. This paper highlights the histomorphologic features of these processes, which are typically characterized by chronic inflammation, immune complex deposition, and immunoproliferative disease in the affected organ.Clinical and Developmental Immunology 08/2012; 2012:740138. DOI:10.1155/2012/740138 · 2.93 Impact Factor
Article: Malignant liver tumors.[Show abstract] [Hide abstract]
ABSTRACT: Primary malignant liver tumors can arise from different components of the liver, such as hepatocytes, bile duct epithelium, neuroendocrine cells, and mesenchymal cells. A specific diagnosis frequently can be suggested from imaging studies, but biopsy remains the gold standard for definitive diagnosis of liver tumors. Clinical history of chronic liver disease, known risk factors, or other diseases are of great importance. Patient's age is also an important discriminating feature because several tumors such as hepatoblastoma, mesenchymal hamartoma, and infantile hemangioendothelioma, are found predominantly in pediatric populations, whereas cholangiocarcinoma and hepatocellular carcinoma are rare in pediatric populations.Clinics in Liver Disease 06/2002; 6(2):527-54, ix. DOI:10.1016/S1089-3261(02)00005-3 · 2.70 Impact Factor