Granulosa cell tumor of the adult type. A case report and review of the literature of a very rare testicular tumor

Departments of Pathology, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 11/2000; 124(10):1525-8. DOI: 10.1043/0003-9985(2000)124<1525:GCTOTA>2.0.CO;2
Source: PubMed


We report a case of testicular granulosa cell tumor of the adult type in a 48-year-old man. Microscopically, the tumor consisted of round to ovoid cells with grooved nuclei that were arranged in several patterns, including microfollicular, macrofollicular, insular, trabecular, gyriform, solid, and pseudosarcomatous. These cells demonstrated strong immunopositivity with MIC2 (O13) antibody, vimentin, and smooth muscle actin and focal positivity with cytokeratin. Although this type of sex cord-stromal tumor is relatively common in the ovaries, it is still extremely unusual in the testis, and it probably represents the rarest type of testicular sex cord-stromal tumor.

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    • "GCTs are sex-cord stromal neoplasms that on microscopic examination contain sex-cord-derived epithelial elements admixed with mesenchymal elements with a variety of combinations and degrees of differentiation [15]. Fibroblasts, granulosa, and theca cells make up a GCT [7]. "
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    ABSTRACT: Background. Granulosa cell tumors (GCTs), representing ~2% of ovarian tumours, are poorly understood neoplasms with unpredictable and undetermined biological behaviour. Design. 5 unusual presentations of GCT and a retrospective 14-year (1997-2011) surgical pathology review based on patient sex, age, tumour type and concurrent pathology findings are presented to discuss the "myths and realities" of GCTs in the context of relevant evidence-based literature. Results. The 5 index cases included (1) a 5 month-old boy with a left testicular mass, (2) a 7-day-old neonate with a large complex cystic mass in the abdomen, (3) a 76-year-old woman with an umbilical mass, (4) a 64-year-old woman with a complex solid-cystic pelvic mass, and (5) a 45 year-old woman with an acute abdomen. Pathological analysis confirmed the final diagnosis as (1) juvenile GCT, (2) macrofollicular GCT, (3) recurrent GCT 32 years later, (4) collision tumour: colonic adenocarcinoma and GCT, and (5) ruptured GCT. Conclusion. GCT is best considered as an unusual indolent neoplasm of low malignant potential with late recurrences that can arise in the ovaries and testicles in both the young and the old. Multifaceted clinical presentations coupled with the unpredictable biological behaviour with late relapses are diagnostic pitfalls necessitating a high degree of suspicion for accurate clinical and pathological diagnosis.
    ISRN obstetrics and gynecology 09/2012; 2012(2):878635. DOI:10.5402/2012/878635
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    • "Granulosa cell tumor is extremely rare in the adult testicle. Only 29 cases of testicular adult type granulosa cell tumor have been previously reported.3–11 A testicular granulosa cell tumor usually presents as a painless mass in the testicle. "
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    ABSTRACT: Granulosa cell tumors can be classified into juvenile and adult types and more commonly occur in ovaries. Adult testicular granulosa cell tumors are extremely rare and only 29 cases of adult type have previously been reported. We report here a 28-year old Caucasian man with a left testicular adult type granulosa cell tumor. The tumor measured 2.6×2.6×2.5 cm and was mitotically active (10/10 HPF). Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin, and negative for epithelial membrane antigen, cytokeratins, synaptophysin, HMB-45, OCT-4, placental-like alkaline phosphatase and lymphoid markers. The reported granulosa cell tumors in adult testis were briefly reviewed.
    Rare tumors 10/2011; 3(4):e37. DOI:10.4081/rt.2011.e37
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    • "As a rule, juvenile GCT is benign and occurs in prepubertal subjects and can be associated either with gonadal dysgenesis or anomalies of the sex chromosomes (Chan et al., 1990; Tanaka et al., 1994; Plesner et al., 2000; Nieto et al., 2002; Shukla et al., 2004). Adult GCT is regarded as a low-grade malignancy, which arises in the scrotal testes of 16–76-year-old men and is sometimes associated with hyperestrogenism (Matoška et al., 1992; Jimenez-Quintero et al., 1993; Al-Bozom et al., 2000; Wang et al., 2002). Testicular GCT has been reported in a CD-1 mouse (Abdi, 1995) and only one GCT was reported among 410 dogs with testicular tumours (Hayes and Pendergrass, 1976). "

    Veterinary Research Communications 09/2005; 29 Suppl 2:169-71. DOI:10.1007/s11259-005-0034-0 · 1.24 Impact Factor
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