Article

Birth outcomes of women with ulcerative colitis: a nationwide Danish cohort study.

The Danish Epidemiology Science Centre and the Department of Epidemiology and Social Medicine, University of Aarhus, Denmark.
The American Journal of Gastroenterology (impact factor: 7.28). 12/2000; 95(11):3165-70. DOI:10.1111/j.1572-0241.2000.03290.x pp.3165-70
Source: PubMed

ABSTRACT Our study aimed to compare the birth outcomes in offspring of women with ulcerative colitis with controls without the disease.
A cohort study of 1531 newborns to mothers with ulcerative colitis, and 9092 controls, based on linkage between the Danish National Registry of Patients and the Danish Birth Registry from 1982 to 1992.
Among the births to women with ulcerative colitis, 569 took place before and 962 after the first hospitalization for ulcerative colitis. We found no increased risk of either low birth weight or intrauterine growth retardation for newborns born before or after the mothers' first hospitalization. The risk of preterm birth was increased when birth occurred after the mothers' first hospitalization (odds ratio = 1.4, 95% confidence interval = 1.1-1.9), and particularly when the first hospitalization for ulcerative colitis took place during pregnancy (odds ratio = 3.4, 95% confidence interval = 1.8-6.4).
In the offspring of women with ulcerative colitis, we found no increased risk of low birth weight or signs of intrauterine growth retardation. The risk of preterm birth was increased in the offspring of women with ulcerative colitis, particularly when the first hospitalization for ulcerative colitis occurred during pregnancy.

0 0
 · 
0 Bookmarks
 · 
26 Views
  • Source
    Article: Pregnancy outcomes in women with inflammatory bowel disease: a large community-based study from Northern California.
    Uma Mahadevan, William J Sandborn, De-Kun Li, Shahbaz Hakimian, Sunanda Kane, Douglas A Corley
    [show abstract] [hide abstract]
    ABSTRACT: The aim of this study was to determine whether pregnancy outcomes differ between women with and without inflammatory bowel disease (IBD) and to determine what risk factors adversely affect outcomes. We conducted a cohort study of all pregnant women within the Northern California Kaiser Permanente membership between the years 1995 and 2002. We abstracted the records of all pregnancies in women with IBD (exposed cohort) and a random sample of pregnancies from age-matched women without IBD (unexposed cohort) and evaluated risk factors for spontaneous abortion, complications of pregnancy, and adverse newborn events. A total of 461 pregnant women with IBD were matched to 493 unexposed pregnant women. Women with IBD were more likely to have an adverse conception outcome (odds ratio, 1.65; 95% confidence interval, 1.09-2.48), an adverse pregnancy outcome (odds ratio, 1.54; 95% confidence interval, 1.00-2.38), or a pregnancy complication (odds ratio, 1.78; 95% confidence interval, 1.13-2.81); however, the difference between the 2 groups in adverse newborn outcomes was not statistically significant (odds ratio, 1.89; 95% confidence interval, 0.98-3.69). Independent predictors of an adverse outcome included a diagnosis of IBD, a history of surgery for IBD, and non-Caucasian ethnicity. Severity of disease and medical treatments were not associated with an adverse outcome. Women with IBD are more likely to have an adverse outcome related to pregnancy. Disease activity and medical treatment did not predict adverse outcomes in a large, nonreferral population.
    Gastroenterology 11/2007; 133(4):1106-12. · 11.68 Impact Factor
  • Source
    Article: A young woman with first-trimester metrorrhagia, fever and skin lesions.
    A Lalueza Blanco, D Rodríguez Alcalde, C González Gómez, G López, P Martínez Montiel, E Sanz García, J A Solís Herruzo
    [show abstract] [hide abstract]
    ABSTRACT: Inflammatory bowel disease commonly affects women with child-bearing potential, and clinical activity extent is most relevant at the time of conception. Below, we report on the case of a 19-year-old woman who was admitted for first-trimester metrorrhagia and fever, with various extraintestinal manifestations, mainly including erythema nodosum and episcleritis during the course of disease. The differential diagnosis of these manifestations led to the diagnosis of Crohn's disease, which involved the whole colon.
    Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 04/2006; 98(3):204-15. · 1.55 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

95% confidence interval
 
birth outcomes
 
births
 
cohort study
 
Danish Birth Registry
 
Danish National Registry
 
first hospitalization
 
increased risk
 
intrauterine growth retardation
 
linkage
 
low birth weight
 
mothers
 
mothers' first hospitalization
 
newborns
 
odds ratio
 
offspring
 
Patients
 
preterm birth
 
ulcerative colitis
 

B Nørgård