Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships.
ABSTRACT This study examined the clinical and familial relationships between comorbid alcoholism and attempted suicide in affectively ill relatives of probands with bipolar I disorder.
In 71 families ascertained for a genetic linkage study, 337 subjects with major affective disorder were assessed by using the Schedule for Affective Disorders and Schizophrenia-Lifetime Version.
Subjects with bipolar disorder and alcoholism had a 38.4% lifetime rate of attempted suicide, whereas those without alcoholism had a 21.7% rate. Attempted suicide among subjects with bipolar disorder and alcoholism clustered in a subset of seven families. Families with alcoholic and suicidal probands had a 40.7% rate of attempted suicide in first-degree relatives with bipolar disorder, whereas other families had a 19.0% rate.
Comorbid alcoholism was associated with a higher rate of attempted suicide among family members with bipolar disorder. Attempted suicide and alcoholism clustered in a subset of families. These relationships may have a genetic origin and may be mediated by intoxication, mixed states, and/or temperamental instability.
- Clinical Neuroscience Research 11/2001; 1(5). · 0.80 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Objective: Bipolar disorder is a recurrent disorder for the vast majority of patients, and hospitalization is normally used to control severe symptoms. The goals of treating bipolar disorder include symptomatic remission, full return of psychosocial functioning, and prevention of relapses/recurrences. Rehospitalization, however, becomes necessary with the relapse/recurrence of severe symptoms. The purpose of the present study was therefore to investigate the risk factors affecting the time to rehospitalization.Australian and New Zealand Journal of Psychiatry 10/2009; 43(10):927-933. · 3.77 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: A genome-wide scan for genetic linkage can suggest fresh insights into disease aetiology. However, in the case of complex disorders such as bipolar affective disorder (BPAD), the results of genome-wide scans must be interpreted with caution. We review 10 published and 10 in-progress genome scans of BPAD, encompassing 3536 affected individuals in 1119 pedigrees. We find that ascertainment methods vary widely, with no two studies using identical methods. Sample sizes and marker densities have generally been well below what is now considered adequate, but several in-progress studies are using larger samples and more closely spaced markers. Few findings reach the 'suggestive' threshold, and fewer still reach the 'significant' threshold at genome-wide levels of significance. Strategies for pooling samples or subjecting findings in different samples to meta-analysis are being developed, but differences in ascertainment methods may have a large impact on the uniformity of different samples and hamper efforts at combining data or findings. There is also a need for methods that help define more genetically homogeneous phenotypes, take into account interactions between multiple susceptibility loci, and accommodate additional complexity (eg parent-of-origin effects) in the search for linkage.Annals of Medicine 07/2009; 33(4). · 4.73 Impact Factor