Plant kingdom as a source of anti-ulcer remedies

Department of Experimental Pharmacology, University of Naples 'Federico II', via D. Montesano 49, 80131 Naples, Italy.
Phytotherapy Research (Impact Factor: 2.66). 01/2001; 14(8):581-91. DOI: 10.1002/1099-1573(200012)14:83.0.CO;2-S
Source: PubMed


Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.

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Available from: Francesca Borrelli, Dec 17, 2014
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    • "Several studies have indicated its pharmacological effects on the central nervous system [2] [3], digestive system [4], cardiovascular system [5] [6], immune system [7], inflammation [8] [9] [10], fatigue [11] [12], tumor [13] [14], and so on. It contains various saponins, polysaccharides, and some active substances like amino acids, volatile oil [15], and so forth. "
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    ABSTRACT: The goal of this study is to investigate the immunoregulative effects of Panax japonicus polysaccharide (PJPS) on mice of low immunity. An orthogonal experiment was designed to determine the best extraction process for PJPS. By the tests of macrophages swallow chicken red blood cells, Delayed-type hypersensitivity (DTH), and serum hemolysin value, we studied the immune adjustment ability of PJPS. MTT was employed to detect the effects of different concentrations of PJPS, respectively, in 24 h, 48 h, and 72 h on five kinds of human cancer cells. The results show that the best extraction process for PJPS was as follows: ratio of solvent consumption to raw material 40, extraction temperature 100°C, re-extracted two times, each extraction time 4 hours. PJPS can significantly improve the immune function of mice processed by cyclophosphamide and PJPS did not work on the above five cancer cells.
    Evidence-based Complementary and Alternative Medicine 09/2015; 2015(12):839697. DOI:10.1155/2015/839697 · 1.88 Impact Factor
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    • "Cymbopogon citratus, family Poaceae, was reported in an ethnoveterinary study as having anthelmintic activity (RITTER et al., 2012). Infusions or decoctions of dry leaves have been utilised as stomachic, antifever, antiseptic, carminative and tranquilising (ARHOGHRO et al., 2012; BORRELLI & IZZO, 2000). In vitro tests with the aqueous extract of C. citratus reduced the burden of Strongyloidea larvae in goats (ALMEIDA et al., 2003). "
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    ABSTRACT: Parasitic nematodes are of major economic importance in livestock. An alternative for the control of parasites is phytotherapy. This study evaluated the efficacy of Cymbopogon citratus decoction (CcD), C. citratus essential oil (CcEo) and citral against Haemonchus contortus using in vitro egg hatch test (EHT) and larval development test (LDT) and an in vivo test using a Meriones unguiculatus (gerbil) model. The effect of 800 mg/kg CcEo was evaluated in gerbils that had been artificially infected with 5,000 third-stage H. contortus larvae. The effective concentrations required to inhibit 50% (EC50) of egg hatching were 0.46, 0.14 and 0.13 mg/mL for CcD, CcEo and citral, respectively. The EC50 values in the LDT were 5.04, 1.92 and 1.37 mg/mL for CcD, CcEo and citral, respectively. H. contortus population in the group treated with C. citratus essential oil was reduced by 38.5% (P< 0.05) in comparison to the control group. These results suggest that it may be possible to use C. citratus essential oil to control of H. contortus parasite of small ruminant.
    Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology: Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria 09/2015; 24(3):268. DOI:10.1590/S1984-29612015059 · 0.87 Impact Factor
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    • "Many compounds from these chemical classes have been shown to possess anti-ulcer properties (Borrelli and Izzo, 2000). Tannins have radical-scavenger properties and, at low concentrations, are known to create a layer in the mucosa and to increase the resistance to chemical and mechanical injury or irritation (Borrelli and Izzo, 2000). Recently, a different group of flavanic dimmers have been identified in lemongrass infusion, which have been correlated with a pronounced anti-radical activity (Costa et al., 2015). "
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    ABSTRACT: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. The study was performed on adult male Wistar rats (234.0±22.7g) fasted for 24hours but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2hours) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. C. citratus extract, given orally before or after ethanol, significantly (P<0.01) reduced gastric mucosal injury compared with control group (vehicle+ethanol). The effect does not appear to be dose-dependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use. Copyright © 2015. Published by Elsevier Ireland Ltd.
    Journal of ethnopharmacology 07/2015; 173. DOI:10.1016/j.jep.2015.07.001 · 3.00 Impact Factor
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