Plant kingdom as a source of anti-ulcer remedies

Department of Experimental Pharmacology, University of Naples 'Federico II', via D. Montesano 49, 80131 Naples, Italy.
Phytotherapy Research (Impact Factor: 2.4). 01/2001; 14(8):581-91. DOI: 10.1002/1099-1573(200012)14:83.0.CO;2-S
Source: PubMed

ABSTRACT Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.

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Available from: Francesca Borrelli, Dec 17, 2014
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    • "Many compounds from these chemical classes have been shown to possess anti-ulcer properties (Borrelli and Izzo, 2000). Tannins have radical-scavenger properties and, at low concentrations, are known to create a layer in the mucosa and to increase the resistance to chemical and mechanical injury or irritation (Borrelli and Izzo, 2000). Recently, a different group of flavanic dimmers have been identified in lemongrass infusion, which have been correlated with a pronounced anti-radical activity (Costa et al., 2015). "
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    ABSTRACT: Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat. The study was performed on adult male Wistar rats (234.0±22.7g) fasted for 24hours but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2hours) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology. C. citratus extract, given orally before or after ethanol, significantly (P<0.01) reduced gastric mucosal injury compared with control group (vehicle+ethanol). The effect does not appear to be dose-dependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases. The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use. Copyright © 2015. Published by Elsevier Ireland Ltd.
    Journal of ethnopharmacology 07/2015; 173. DOI:10.1016/j.jep.2015.07.001 · 2.94 Impact Factor
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    • "Several natural products have demonstrated antibacterial activity against H. pylori (Nostro et al., 2005) and for centuries a wide variety of plants and substances derived from plants have been used to treat gastrointestinal disorders (Borrelli and Izzo, 2000). Many plants used to treat this infection do not present any scientific evidence of efficacy for anti-H. "
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    ABSTRACT: Research on plants has as its purpose the development of new drugs to treat diseases that affect humans. The increasing prevalence of multidrug resistant strains of bacteria and the recent appearance of strains with reduced susceptibility to antibiotics raises the specter of untreatable bacterial infections and adds urgency to the search for brand new infection-fighting strategies. Current advancements in drug discovery technology and search for new drugs from plants have always been of great interest for the scientists working in this field. The biological activity of methanolic extracts of Castela texana and Stenocereus marginatus was evaluated in vitro in the growth of Helicobacter pylori, both extracts inhibited the growth, but the methanolic extract of S. marginatus completely inhibited biofilm formation; this structure is important for the protection of H. pylori and increased resistance to antimicrobial agents. The toxicity was determined in Artemia salina; the methanolic extract of S. marginatus is less toxic than the extract of C. texana. The phytochemical analysis of the methanolic extract of S. marginatus revealed that potential secondary metabolites with anti-H. pylori activity are flavones, sesquiterpene lactones and alkaloids. As a result, future research should be conducted to obtain pure substances from S. marginatus for possible treatment of H. pylori.
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    • "In addition to favanones, orange fruits are characterized by the presence of flavones (Bonaccorsi, McNair, Brunner, Dugo, & Dugo, 1999; Russo, Cacciola, Bonaccorsi, Dugo, & Mondello, 2011; Donato, Bonaccorsi, Russo, & Dugo, 2014). In general flavanones and flavones exhibit beneficial effects on capillary fragility, anti-inflammatory, antimicrobial and antiviral activities , and possess the capability to inhibit human platelet aggregation, antiallergenic, and antiulcer properties and hypocholesterolemic effects (Borrelli & Izzo, 2000; Di Donna et al., 2014; Middleton & Kandaswami, 1992; Tijburg, Mattern, Folts, Weisgerber, & Katan, 1997; Wightman, 2004). Recently it has also been proven that C-and O-glycosyl flavone possess high scavenging properties (Barreca, Bellocco, Leuzzi, & Gattuso, 2014) and that they act as protecting agents against oxidative stress (Bernabé et al., 2013). "
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    ABSTRACT: This study reports a comprehensive investigation on the presence of flavonoids, limonoids and dietary fiber determined by HPLC in all the by-products of the industrial transforma- tion of orange. Seeds were the richest source of bioactive molecules, with flavanones being the most abundant, followed by phenolic acids (238 mg/kg). However, p-hydroxybenzoic acid and caffeic acid were highly represented also in the exhausted peels and pulps (560 mg/ kg). Limonoids were determined exclusively in seeds.Among all the by-products it was found that waste water is extremely rich of hesperidin (19,500 mg/kg). For this reason an only eco- friendly preparative HPLC method for the recovery and purification of hesperidin from waste water was developed. Dietary fiber was determined in exhausted peels and pulps which resulted to be rich sources of insoluble dietary fiber.The results show that the by-products here investigated represent important sources of nutraceuticals as ingredients useful for functional food preparation
    Journal of Functional Foods 01/2015; 12:150-157. · 4.48 Impact Factor
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