Article

High-performance liquid chromatographic assay of trandolapril in capsules.

Department of Medicinal Chemistry, Medical Academy 6 Chodźki Str., 20-093 Lublin, Poland.
Acta poloniae pharmaceutica (impact factor: 0.66). 57(4):253-5. pp.253-5
Source: PubMed

ABSTRACT Rapid, simple and accurate chromatographic (HPLC) method for the determination of trandolapril was elaborated. Samples were chromatographed on a LiChrosorb RP-18 column and the mobile phase was acetonitrile -0.067 M phosphate buffer pH 2.7 (7:3, v/v). The UV detection at 220 nm and benazepril as an internal standard were used. The method was tested for linearity (over the range 4-20 micrograms.ml-1), precision and accuracy and was successfully applied for the quantitative determination of trandolapril in capsules.

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Keywords

accurate chromatographic
 
LiChrosorb RP-18 column
 
linearity
 
mobile phase
 
quantitative determination
 
range 4-20 micrograms.ml-1
 
Rapid
 
Samples
 
UV detection