Speech perception deficit in dyslexic adults as measured by mismatch negativity (MMN)

Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans-Sachs-Strasse 6, 35039, Marburg, Germany.
International Journal of Psychophysiology (Impact Factor: 2.88). 03/2001; 40(1):77-87. DOI: 10.1016/S0167-8760(00)00152-5
Source: PubMed


Deficits in phonological processing are known to play a major role in the aetiology of dyslexia, and speech perception is a prerequisite condition for phonological processing. Significant group differences between dyslexics and controls have been found in the categorical perception of synthetic speech stimuli. In a previous work, we have demonstrated that these group differences are already present at an early pre-attentive stage of signal processing in dyslexic children: the late component of the MMN elicited by passive speech perception was attenuated in comparison to a control group. In this study, 12 dyslexic adults and 13 controls were assessed using a passive oddball paradigm. Mismatch negativity (MMN) was determined for both tone and speech stimuli. The tone stimuli yielded two MMN components, but no group differences. Three components were found for the speech stimuli. Multivariate testing for group differences yielded a significant result, and univariate P values revealed significant differences between dyslexics and controls in two of the three time windows. This suggests that speech perception as measured on an early, pre-attentive level plays a major role in dyslexia not only in children (as shown in our previous study) but also in adults.

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Available from: Jürgen Bartling, Oct 05, 2015
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    • "The late MC has been reported to reflect the summation of MMN generators and memory trace formation on gestalt bases [22] and is observed in response to changes in unattended speech or nonspeech stimuli [23], from new born infants [23, 24], children [22, 23], and adults [25]. It has been suggested that the late MC, like the classic MMN, is a prominent tool in studying speech perception and learning [23]. "
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    ABSTRACT: This study investigates the effect of tone inventories on brain activities underlying pitch without focal attention. We find that the electrophysiological responses to across-category stimuli are larger than those to within-category stimuli when the pitch contours are superimposed on nonspeech stimuli; however, there is no electrophysiological response difference associated with category status in speech stimuli. Moreover, this category effect in nonspeech stimuli is stronger for Cantonese speakers. Results of previous and present studies lead us to conclude that brain activities to the same native lexical tone contrasts are modulated by speakers' language experiences not only in active phonological processing but also in automatic feature detection without focal attention. In contrast to the condition with focal attention, where phonological processing is stronger for speech stimuli, the feature detection (pitch contours in this study) without focal attention as shaped by language background is superior in relatively regular stimuli, that is, the nonspeech stimuli. The results suggest that Cantonese listeners outperform Mandarin listeners in automatic detection of pitch features because of the denser Cantonese tone system.
    Computational and Mathematical Methods in Medicine 08/2014; 2014:961563. DOI:10.1155/2014/961563 · 0.77 Impact Factor
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    • "Several studies have investigated the relationship between successful written language acquisition and MMN amplitude (e.g., Corbera, 2006; Kujala, 2000, 2001). Schulte-Körne et al. (1998) and Schulte-Körne (2001) showed that differences regarding the MMN amplitude between children and adults with and without dyslexia can only be observed in response to speech sounds. No difference was reported for nonspeech sounds. "
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    ABSTRACT: These days, illiteracy is still a major problem. There is empirical evidence that auditory phoneme discrimination is one of the factors contributing to written language acquisition. The current study investigated auditory phoneme discrimination in participants who did not acquire written language sufficiently. Auditory phoneme discrimination was analyzed in illiterate adults and literate controls by recording event-related brain potentials (ERPs) while participants listened to standard and deviant phonemes (oddball paradigm). The results showed that only literate controls yielded mismatch negativity (MMN), the characteristic ERP marker for auditory discrimination. In illiterates, no discernible MMN was observed. These findings indicate the importance of written language acquisition for the development and maintenance of auditory phoneme discrimination. The reduced ability in discriminating phonemes in adult illiterates suggests potential training measures concerning literacy acquisition in these adults. (PsycINFO Database Record (c) 2013 APA, all rights reserved).
    Developmental Psychology 02/2013; 49(11). DOI:10.1037/a0031765 · 3.21 Impact Factor
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    • "Based on the observed scalp topography of the MMN in the control group and on electrode choice in previous MMN studies, the following fronto-central electrodes were chosen for analysis: F3, F4, Fz, C3, C4, Cz, Fc3, Fc4, Fcz. This fronto-central region is also known to be of interest for auditory stimulus perception and processing [67] and these electrodes were also used for group comparisons between dyslexic probands and controls in former speech perception studies [18], [19]. The grand average wave forms (figure 1) revealed three MMN components: labelled MMN1, MMN2, and late MMN. "
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    ABSTRACT: Dyslexia affects 5-10% of school-aged children and is therefore one of the most common learning disorders. Research on auditory event related potentials (AERP), particularly the mismatch negativity (MMN) component, has revealed anomalies in individuals with dyslexia to speech stimuli. Furthermore, candidate genes for this disorder were found through molecular genetic studies. A current challenge for dyslexia research is to understand the interaction between molecular genetics and brain function, and to promote the identification of relevant endophenotypes for dyslexia. The present study examines MMN, a neurophysiological correlate of speech perception, and its potential as an endophenotype for dyslexia in three groups of children. The first group of children was clinically diagnosed with dyslexia, whereas the second group of children was comprised of their siblings who had average reading and spelling skills and were therefore "unaffected" despite having a genetic risk for dyslexia. The third group consisted of control children who were not related to the other groups and were also unaffected. In total, 225 children were included in the study. All children showed clear MMN activity to/da/-/ba/contrasts that could be separated into three distinct MMN components. Whilst the first two MMN components did not differentiate the groups, the late MMN component (300-700 ms) revealed significant group differences. The mean area of the late MMN was attenuated in both the dyslexic children and their unaffected siblings in comparison to the control children. This finding is indicative of analogous alterations of neurophysiological processes in children with dyslexia and those with a genetic risk for dyslexia, without a manifestation of the disorder. The present results therefore further suggest that the late MMN might be a potential endophenotype for dyslexia.
    PLoS ONE 05/2012; 7(5):e34909. DOI:10.1371/journal.pone.0034909 · 3.23 Impact Factor
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