Article

Speech perception deficit in dyslexic adults as measured by mismatch negativity (MMN)

Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans-Sachs-Strasse 6, 35039, Marburg, Germany.
International Journal of Psychophysiology (Impact Factor: 2.65). 03/2001; 40(1):77-87. DOI: 10.1016/S0167-8760(00)00152-5
Source: PubMed

ABSTRACT Deficits in phonological processing are known to play a major role in the aetiology of dyslexia, and speech perception is a prerequisite condition for phonological processing. Significant group differences between dyslexics and controls have been found in the categorical perception of synthetic speech stimuli. In a previous work, we have demonstrated that these group differences are already present at an early pre-attentive stage of signal processing in dyslexic children: the late component of the MMN elicited by passive speech perception was attenuated in comparison to a control group. In this study, 12 dyslexic adults and 13 controls were assessed using a passive oddball paradigm. Mismatch negativity (MMN) was determined for both tone and speech stimuli. The tone stimuli yielded two MMN components, but no group differences. Three components were found for the speech stimuli. Multivariate testing for group differences yielded a significant result, and univariate P values revealed significant differences between dyslexics and controls in two of the three time windows. This suggests that speech perception as measured on an early, pre-attentive level plays a major role in dyslexia not only in children (as shown in our previous study) but also in adults.

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    • "Several studies have investigated the relationship between successful written language acquisition and MMN amplitude (e.g., Corbera, 2006; Kujala, 2000, 2001). Schulte-Körne et al. (1998) and Schulte-Körne (2001) showed that differences regarding the MMN amplitude between children and adults with and without dyslexia can only be observed in response to speech sounds. No difference was reported for nonspeech sounds. "
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    • "Both genes, KIAA0319 and DCDC2, are expressed in brain regions (i.e. temporal and occipital, inferior temporo-occipital region of the left hemisphere) that show functional relevance for cognitive processes such as grapheme phoneme association (van Atteveldt et al. 2004) and speech perception related to reading and spelling development (Blau et al. 2009; Schulte-Körne et al. 2001b). "
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    • "They concluded that DD children have a specific weakness in the passive perception of speech. Our findings in adults are somewhat in agreement with those from the other study (Schulte-Korne et al., 2001) which found significantly smaller LDN in DD adults in response to changes in speech stimuli. "
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