Speech perception deficit in dyslexic adults as measured by mismatch negativity (MMN)

Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans-Sachs-Strasse 6, 35039, Marburg, Germany.
International Journal of Psychophysiology (Impact Factor: 2.65). 03/2001; 40(1):77-87. DOI: 10.1016/S0167-8760(00)00152-5
Source: PubMed

ABSTRACT Deficits in phonological processing are known to play a major role in the aetiology of dyslexia, and speech perception is a prerequisite condition for phonological processing. Significant group differences between dyslexics and controls have been found in the categorical perception of synthetic speech stimuli. In a previous work, we have demonstrated that these group differences are already present at an early pre-attentive stage of signal processing in dyslexic children: the late component of the MMN elicited by passive speech perception was attenuated in comparison to a control group. In this study, 12 dyslexic adults and 13 controls were assessed using a passive oddball paradigm. Mismatch negativity (MMN) was determined for both tone and speech stimuli. The tone stimuli yielded two MMN components, but no group differences. Three components were found for the speech stimuli. Multivariate testing for group differences yielded a significant result, and univariate P values revealed significant differences between dyslexics and controls in two of the three time windows. This suggests that speech perception as measured on an early, pre-attentive level plays a major role in dyslexia not only in children (as shown in our previous study) but also in adults.

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Available from: Jürgen Bartling, Aug 11, 2015
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    • "Several studies have investigated the relationship between successful written language acquisition and MMN amplitude (e.g., Corbera, 2006; Kujala, 2000, 2001). Schulte-Körne et al. (1998) and Schulte-Körne (2001) showed that differences regarding the MMN amplitude between children and adults with and without dyslexia can only be observed in response to speech sounds. No difference was reported for nonspeech sounds. "
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    Developmental Psychology 02/2013; 49(11). DOI:10.1037/a0031765 · 3.21 Impact Factor
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    • "Both genes, KIAA0319 and DCDC2, are expressed in brain regions (i.e. temporal and occipital, inferior temporo-occipital region of the left hemisphere) that show functional relevance for cognitive processes such as grapheme phoneme association (van Atteveldt et al. 2004) and speech perception related to reading and spelling development (Blau et al. 2009; Schulte-Körne et al. 2001b). "
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    ABSTRACT: It has been repeatedly shown that mismatch negativity (MMN), an event related potential measurement, reveals differences between dyslexic children and age-matched controls. MMN reflects the automatic detection of deviance between a stream of incoming sounds presented to the passive listener, and deficits in MMN (i.e. attenuated amplitudes) have been especially reported in dyslexia for detecting differences between speech sounds (e.g./ba/vs./da/). We performed an association analysis in 200 dyslexic children. This analysis focused on two MMN components, an early MMN (188-300 ms) and a late MMN (300-710 ms), and the dyslexia candidate genes KIAA0319 and DCDC2 on chromosome 6. Additionally, we imputed rare variants located in this region based on the 1000 genomes project. We identified four rare variants that were significantly associated with the late MMN component. For three of these variants, which were in high LD to each other, genotyping confirmed the association signal. Our results point to an association between late MMN and rare variants in a candidate gene region for dyslexia.
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    • "They concluded that DD children have a specific weakness in the passive perception of speech. Our findings in adults are somewhat in agreement with those from the other study (Schulte-Korne et al., 2001) which found significantly smaller LDN in DD adults in response to changes in speech stimuli. "
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