Speech perception deficit in dyslexic adults as measured b mismatch negativity (MMN)

Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans-Sachs-Strasse 6, 35039, Marburg, Germany.
International Journal of Psychophysiology (Impact Factor: 2.88). 03/2001; 40(1):77-87. DOI: 10.1016/S0167-8760(00)00152-5
Source: PubMed


Deficits in phonological processing are known to play a major role in the aetiology of dyslexia, and speech perception is a prerequisite condition for phonological processing. Significant group differences between dyslexics and controls have been found in the categorical perception of synthetic speech stimuli. In a previous work, we have demonstrated that these group differences are already present at an early pre-attentive stage of signal processing in dyslexic children: the late component of the MMN elicited by passive speech perception was attenuated in comparison to a control group. In this study, 12 dyslexic adults and 13 controls were assessed using a passive oddball paradigm. Mismatch negativity (MMN) was determined for both tone and speech stimuli. The tone stimuli yielded two MMN components, but no group differences. Three components were found for the speech stimuli. Multivariate testing for group differences yielded a significant result, and univariate P values revealed significant differences between dyslexics and controls in two of the three time windows. This suggests that speech perception as measured on an early, pre-attentive level plays a major role in dyslexia not only in children (as shown in our previous study) but also in adults.

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    • ") is the only study in which a smaller LDN response was found. In contrast , in studies in which the difference in sound frequency of stimuli is large (> 10%), group differences are not statistically detectable (Hämäläinen Leppänen, Guttorm, & Lyytinen, 2008; Meng et al., 2005; Schulte-Körne, Deimel, Bartling, & Remschmidt, 2001; Sharma et al., 2006). Bishop (2007), in her review of findings of ERP studies of frequency processing in individuals with language impairment and dyslexia , arrived at a similar conclusion regarding the processing of small and large differences in sound frequency among those with dyslexia. "

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    • "The late MC has been reported to reflect the summation of MMN generators and memory trace formation on gestalt bases [22] and is observed in response to changes in unattended speech or nonspeech stimuli [23], from new born infants [23, 24], children [22, 23], and adults [25]. It has been suggested that the late MC, like the classic MMN, is a prominent tool in studying speech perception and learning [23]. "
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