Albunex Does Not Increase the Sensitivity of the Lung to Pulsed Ultrasound.
ABSTRACT If cavitation in the vasculature of the lung is the physical mechanism responsible for lung hemorrhage, then addition of cavitation nuclei to the blood should enhance the bioeffect. To test the cavitation hypothesis, the extent of lung hemorrhage in mice injected with the echocontrast agent, Albunex(R), was compared to lung hemorrhage in animals injected with saline. Animals were exposed for 5 minutes to 1.1-MHz pulsed ultrasound (10 µs pulse length, 100-Hz pulse repetition frequency) at a peak positive pressure at the surface of the animal of 2 MPa. This exposure is approximately twice the threshold pressure amplitude for lung hemorrhage. Lesion areas did not differ significantly in the two groups of animals and were approximately equal to the lesion area in uninjected mice from an earlier study where acoustic exposures were the same. Neither this study nor a related study of hemolysis in vivo suggests that use of Albunex in echocardiographic procedures increases the risk of bioeffects.
European Journal of Ultrasound 07/1999; 9(3):277-280. DOI:10.1016/S0929-8266(99)00045-2
Acta Radiologica 07/2013; 54(6):599-600. DOI:10.1177/0284185113484894 · 1.35 Impact Factor
Article: Safety of Ultrasonographic Agents[Show abstract] [Hide abstract]
ABSTRACT: Microbubble contrast agents for ultrasound have gained increasing interest in recent years ( Quaia 2007). It is generally considered that ultrasound contrast agents approved for clinical use are well tolerated and serious adverse reactions are rarely observed. In this chapter, the evidence supporting this impression is reviewed.