[The specificity of lipid metabolism in hereditary arterial hypertension induced by stress].

Abstract

Studies of lipid metabolites in the plasma and lymph of rats with hereditary arterial hypertension induced by stress (HAHIS) showed decreased plasma and lymph pool of total cholesterol (TC) in comparison with normotensive Wistar rats. In HAHIS animals, TC concentration in the lymph was lower than in the plasma. The concentrations of triglycerides and free fatty acids in the plasma and lymph of hypertensive animals were virtually the same and higher than in normotensive ones. Plasma concentration of malonic dialdehyde (MDA) in HAHIS rats was the same as in Wistar rats, while the lymph concentration of MDA was higher than in Wistar rats. The detected lipid metabolism characteristics reflect its genotypical and phenotypical rearrangement and are a component of the "metabolic syndrome", detected in patients with essential hypertension and animals with spontaneous arterial hypertension.