Article

Primary Cutaneous T-Cell–Rich B-Cell Lymphoma: Clinically Distinct from Its Nodal Counterpart?

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
Modern Pathology (Impact Factor: 6.36). 02/2001; 14(1):10-3. DOI: 10.1038/modpathol.3880250
Source: PubMed

ABSTRACT The cases of two patients with Stage IE primary cutaneous T-cell-rich B-cell lymphoma (TCRBCL) are described. In both, the lesion showed a dense infiltrate by numerous small T lymphocytes with scattered histiocytes and large atypical B-lymphoid cells. Polymerase chain reaction assays demonstrated that the B cells were monoclonal, with immunoglobulin heavy-chain gene rearrangement. No clonal rearrangements of the T-cell receptor gamma gene were observed. Both patients were disease-free at 4 months and at 5 years after therapy, respectively. Although rare, primary cutaneous T-cell-rich B-cell lymphoma appears to have a better prognosis than its nodal counterpart, with or without skin involvement.

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Available from: Shiyong Li, Apr 17, 2014
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