Genomics and behavior - Toward behavioral genomics
ABSTRACT The genetic influences on behavior are even more difficult to tease out than the genetic bases of complex diseases. But
discuss how the ultimate availability of the complete genome sequences of many individuals will offer a solution to this problem.
The sequencing of the human genome has opened the door to obtaining extensive maps of markers for single nucleotide variations
among people. This information will allow the use of allelic association, a method for identifying the genes that contribute
to variations in behavior among people and to complex behavioral disorders.
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ABSTRACT: The thalamus is a crucial node for brain physiology and part of functional and structural pathways relevant for schizophrenia. Relatively few imaging studies on schizophrenia have focused on this brain region, yet extant evidence supports the association between this brain disorder and thalamic anomalies. Nevertheless, the mechanisms underlying this association remain largely conjectural. Here, we review imaging literature on the relationship between the thalamus and schizophrenia, focusing on critical challenges for future studies, in particular: i. the anatomical and functional organization of the thalamus in separate nuclei, which are also differently connected with the cortex; ii. state-dependent variables, which do not allow firm conclusions on the relevance of thalamic correlates as core phenotypes of schizophrenia; iii. genetic variation, which affects thalamic physiology and may lead to variability of structural and functional patterns. Current evidence from the studies reviewed does not appear conclusive, although the relevance of thalamo-prefrontal interactions clearly emerges. Results from imaging genetics are beginning to cast insight on possible mechanisms of the involvement of the thalamus in schizophrenia. Copyright © 2015. Published by Elsevier Ltd.Neuroscience & Biobehavioral Reviews 01/2015; DOI:10.1016/j.neubiorev.2015.01.013 · 10.28 Impact Factor