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Martinon, F., Hofman, K. & Tschopp, J. The pyrin domain: a possible member of the death domain family implicated in apoptosis and inflammation. Curr. Biol. 11, R118-R120

Current Biology (Impact Factor: 9.92). 03/2001; 11(4):R118-20. DOI: 10.1016/S0960-9822(01)00056-2
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    • "The adaptor ASC (also known as PYCARD) has an N-terminal PYD that facilitates interactions with the PYD domain of NLRs, and a C-terminal CARD domain that recruits caspase-1 through CARD-CARD interactions (Martinon et al., 2001). Interestingly, besides its role as an adaptor, ASC is required to induce autoproteolysis of pro-caspase-1 in the inflammasome complex, a prerequirement for efficient cytokine processing (Broz et al., 2010b). "
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    • "This protein – protein interaction domain links specific components of the apoptosis regulatory pathways. Accordingly, PYD domain is frequently found in regulators of inflammatory immune responses and apoptosis [5]. For instance, an adaptor protein, apoptosis-associated speck-like "
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    • "NALP proteins contain an amino-terminal PYD and carboxyterminal LRR region. PYD domains are present in the members of the death superfamily (Martinon et al., 2001; Pawlowski et al., 2001). Proteins carrying a PYD are mainly involved in inflammation, apoptosis and NF-kB transcription factor signalling (Koonin and Aravind, 2000; Hoffman et al., 2001; Gumucio et al., 2002). "
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