McGill HC, McMahan CA, Zieske AW, Malcom GT, Tracy RE, Strong JP. Effect of nonlipid risk factors on atherosclerosis in youth with favorable lipoprotein profile. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Circulation 103, 1546-1550

University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Circulation (Impact Factor: 14.43). 03/2001; 103(11):1546-50. DOI: 10.1161/01.CIR.103.11.1546
Source: PubMed


The strong association between coronary heart disease and dyslipoproteinemia has often overshadowed the effects of the nonlipid risk factors-smoking, hypertension, obesity, and diabetes and impaired glucose tolerance-and even led to questioning the importance of these risk factors in the presence of a favorable lipoprotein profile.
A cooperative multicenter study, the Pathobiological Determinants of Atherosclerosis in Youth (PDAY), examined the relation of the nonlipid risk factors to atherosclerosis in 629 men and 227 women 15 to 34 years of age who died of external causes and who had a favorable lipoprotein profile (non-HDL cholesterol <4.14 mmol/L [<160 mg/dL] and HDL cholesterol >/=0.91 mmol/L [>/=35 mg/dL]). In the abdominal aorta, smokers had more extensive fatty streaks and raised lesions than nonsmokers, and hypertensive blacks had more raised lesions than normotensive blacks. In the right coronary artery, hypertensive blacks had more raised lesions than normotensive blacks, obese men (body mass index >/=30 kg/m(2)) had more extensive fatty streaks and raised lesions than nonobese men, and individuals with impaired glucose intolerance had more extensive fatty streaks. Obese men had more severe lesions (American Heart Association grade 2 through 5) of the left anterior descending coronary artery.
These substantial effects of the nonlipid risk factors on the extent and severity of coronary and aortic atherosclerosis, even in the presence of a favorable lipoprotein profile, support the need to control all cardiovascular risk factors.

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    • "ICAM-1, VCAM-1) that mediate monocyte homing [3] [4]. In diabetic mouse models, chronic hyperglycemia is strongly associated with the formation of early plaques, termed fatty streaks [5], and postmortem analysis of young patients and children with type 1 diabetes show enhanced fatty streak formation [6] [7], suggesting that hyperglycemia promotes early plaque development. While recent clinical trials (ACCORD, ADVANCE) failed to find a significant effect of stringent glucose control on cardiovascular outcomes in diabetic patients [8] [9], these data may result from the timing of glycemic control, as 10 year follow-ups of the DCCT and UKPDS trials found that tight glycemic control early following diagnosis of diabetes significantly decreases cardiovascular events [10] [11]. "
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    ABSTRACT: Objective Altered subendothelial matrix composition regulates endothelial dysfunction and early atherosclerotic plaque formation. Hyperglycemia promotes endothelial matrix remodeling associated with multiple microvascular complications of diabetes, but a role for altered matrix composition in diabetic atherogenesis has not been described. Therefore, we sought to characterize the alterations in matrix composition during diabetic atherogenesis using both in vitro and in vivo model systems. Methods and Results Streptozotocin-induced diabetes in atherosclerosis-prone ApoE knockout mice promoted transitional matrix expression (fibronectin, thrombospondin-1) and deposition in intima of the aortic arch as determined by qRT-PCR array and immunohistochemistry. Early plaque formation occurs at discrete vascular sites exposed to disturbed blood flow patterns, whereas regions exposed to laminar flow are protected. Consistent with this pattern, hyperglycemia-induced transitional matrix deposition was restricted to regions of disturbed blood flow. Laminar flow significantly blunted high glucose-induced fibronectin expression (mRNA and protein) and fibronectin fibrillogenesis in endothelial cell culture models, whereas high glucose-induced fibronectin deposition was similar between disturbed flow and static conditions. Conclusions Taken together, these data demonstrate that flow patterns and hyperglycemia coordinately regulate subendothelial fibronectin deposition during early atherogenesis.
    Atherosclerosis 01/2013; 232(2). DOI:10.1016/j.atherosclerosis.2013.11.052 · 3.99 Impact Factor
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    • "Taken together, it is suggested that absolutely equal exercise volume without consideration of subject's body weight may explain the current controversy in _ V O 2max enhancement among different exercise intensity groups. Blood lipids are well documented as a contributing factor, leading to the pathogenesis of atherosclerosis, which is the underlying cause of coronary heart disease (McGill et al. 2001), and are known to be favorably affected by endurance exercise training (Leon and Sanchez 2001). We identified that a number of risk factors are unaltered by either highintensity or low-intensity exercise training in the present study. "
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    ABSTRACT: The primary purpose of this study was to investigate the effects of high-intensity exercise training under relatively equal energy expenditure on whole body fat and abdominal fat loss, and cardiorespiratory fitness. Twenty-two untrained middle-aged Korean females were randomized into one of the following groups: control, low-intensity training group (LI), and high-intensity training group (HI). Subjects completed 14 weeks of training at 50% maximal oxygen consumption (LI) or 70% maximal oxygen consumption (HI) with the volume of exercise equated relative to kilograms of body weight. Weekly exercise volumes were 13.5 METs⋅h/week for the first 4 weeks, 18 METs⋅h/week for next 5 weeks, and 22.5 METs⋅h/week for the final 5 weeks. Data were analyzed using 2-way repeated measures ANOVA with post hoc test, using Bonferroni's correction. HI showed significant reductions in fat mass (p < 0.05), total abdominal fat (p < 0.01), and subcutaneous abdominal fat (p < 0.01). LI reduced total abdominal fat (p < 0.05), but there were no other significant changes found in the control or LI groups. Maximal oxygen consumption was enhanced in both HI and LI with no significant group difference. High-density lipoprotein cholesterol increased significantly in HI (p < 0.05). IL-6, C-reactive protein, TNF-α, and other blood lipids were unaltered following training. Results indicate that high-intensity exercise training is more beneficial in whole body and abdominal fat loss; however, cardiorespiratory enhancement shows a dose-response relationship with weekly exercise volume. It is suggested that 14 weeks of aerobic exercise training at either high- or low-intensity is not sufficient enough to induce changes in levels of inflammatory proteins.
    Applied Physiology Nutrition and Metabolism 08/2012; 37(6). DOI:10.1139/h2012-084 · 2.34 Impact Factor
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    • "Obese children and adolescents are also more likely to seek treatment for depression [9], are more likely to be stigmatized and discriminated against [10, 11], and are more likely to have disturbed eating patterns than normal weight children and adolescents [12]. With regard to objective health, children and adolescents with overweight and obesity are more likely to suffer from metabolic syndrome (hyperinsulinemia, poor glucose tolerance, dyslipidemias, and high blood pressure) [14, 15], as well as from type-2 diabetes [16], atherosclerosis [17–19], asthma [20], nonalcoholic fatty liver disease (a chronic liver disease that may result in liver cancer) [21, 22, 27], and sleep-associated breathing disorders [28, 29]. Moreover, since childhood overweight and obesity often track into adulthood [23], the health consequences related to overweight and obesity frequently persist and culminate later in life. "
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    ABSTRACT: Experts stress the need to bring the childhood obesity epidemic under control by means of an integrated approach. The implementation of such an approach requires the development of integrated enabling policies on public health by local governments. A prerequisite for developing such integrated public health policies is intersectoral collaboration. Since the development of integrated policies is still in its early stages, this study aimed to answer the following research question: "What interventions can promote intersectoral collaboration and the development of integrated health policies for the prevention of childhood obesity?" Data were collected through a literature search and observations of and interviews with stakeholders. Based on a theoretical framework, we categorized potential interventions that could optimize an integrated approach regarding children's physical activity and diet. The intervention categories included education, persuasion, incentivization, coercion, training, restriction, environmental restructuring, modeling, and enablement.
    Journal of Environmental and Public Health 06/2012; 2012(1):913236. DOI:10.1155/2012/913236
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