Factor Analysis of Computerized and Traditional Tests Used in Mild Brain Injury Research

National Rehabilitation Hospital, Washington DC 20010, USA.
The Clinical Neuropsychologist (Impact Factor: 1.72). 09/2000; 14(3):287-94. DOI: 10.1076/1385-4046(200008)14:3;1-P;FT287
Source: PubMed

ABSTRACT The present study examines the relation between a set of computerized neuropsychological measures, Automated Neuropsychological Assessment Metrics (ANAM), and a set of traditional clinical neuropsychological tests. Both sets of tests have been employed in recent studies of mild brain injury. Factor analysis and stepwise regression indicate that both sets of tests measure similar underlying constructs of cognitive processing speed, resistance to interference, and working memory. The present findings indicate strong concordance between computerized and traditional neuropsychological measures and support the construct validity of ANAM and similar procedures.

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Available from: Joseph Bleiberg, Sep 26, 2015
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    • "Reported parameters include the mean reaction time for each session and parameter, as well as a calculated Tput statistic that represents the number of correct responses per minute of available time to respond. The complete protocol has been previously described [14] and validated elsewhere [21, 22]. "
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    ABSTRACT: Background. Momentary lapses in concentration contribute to workplace accidents. Given that blood glucose (BG) and hydration levels have been shown to affect vigilance, this study proposed to investigate these parameters and functional movement patterns of ski-resort workers and to determine whether an educational program to stabilize BG and hydration and encourage joint stability had an effect in decreasing occupational injuries. Methods. Seventy-five instructors, patrollers and, lift-operators at five snowsport resorts were evaluated for BG, vigilance, workload, dietary/hydration practices, and functional-movement patterns. Injury rates were tabulated before and after an educational program for nutrition and functional-movement awareness and compared to other resorts. Results. Workers showed poor stability at the lumbar spine, knee, and shoulder. BG levels were normal but variable (%CV = 14 ± 6). Diets were high in sugar and fat and low in water and many nutrients. Medical Aid and Lost Time claims declined significantly by 65.1 ± 20.0% (confidence interval −90.0% ≤μ ≤ −40.2%) in resorts that used the educational program whereas four control resorts not using the program experienced increases of 33.4 ± 42.9% (confidence interval −19.7% ≤μ ≤ −86.7%; F[2,12] = 21.35, P < 0.0001 ) over the same season. Conclusion. Provision of snowsport resort workers with educational programs encouraging hydration, diet to stabilize BG, and functional-movement awareness was effective in reducing worksite injuries in this population.
    07/2013; 2013(2):121832. DOI:10.1155/2013/121832
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    • "Based on the manufacturer's recommendation, subjects completed three practice tests prior to baseline data collection. This approach eliminates any learning effect during the study period and prevents learning effects from confounding actual study measurements [20-22]. "
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    ABSTRACT: Physicians are often unable to eat and drink properly during their work day. Nutrition has been linked to cognition. We aimed to examine the effect of a nutrition based intervention, that of scheduled nutrition breaks during the work day, upon physician cognition, glucose, and hypoglycemic symptoms. A volunteer sample of twenty staff physicians from a large urban teaching hospital were recruited from the doctors' lounge. During both the baseline and the intervention day, we measured subjects' cognitive function, capillary blood glucose, "hypoglycemic" nutrition-related symptoms, fluid and nutrient intake, level of physical activity, weight, and urinary output. Cognition scores as measured by a composite score of speed and accuracy (Tput statistic) were superior on the intervention day on simple (220 vs. 209, p = 0.01) and complex (92 vs. 85, p < 0.001) reaction time tests. Group mean glucose was 0.3 mmol/L lower (p = 0.03) and less variable (coefficient of variation 12.2% vs. 18.0%) on the intervention day. Although not statistically significant, there was also a trend toward the reporting of fewer hypoglycemic type symptoms. There was higher nutrient intake on intervention versus baseline days as measured by mean caloric intake (1345 vs. 935 kilocalories, p = 0.008), and improved hydration as measured by mean change in body mass (+352 vs. -364 grams, p < 0.001). Our study provides evidence in support of adequate workplace nutrition as a contributor to improved physician cognition, adding to the body of research suggesting that physician wellness may ultimately benefit not only the physicians themselves but also their patients and the health care systems in which they work.
    BMC Health Services Research 08/2010; 10(1):241. DOI:10.1186/1472-6963-10-241 · 1.71 Impact Factor
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    • "p b 10e-5, n 2 = 0.174 HC N E, D, HM E N D Sum of all significant factors only (n = 7) Factors 1–3, 4–8 F(3, 152) = 12.35, p b 10e-6, n 2 = 0.196 HC N E, D, HM E N D processing. Due to the large number of dependent variables in the neuropsychological tests, standard data reduction techniques were used to reduce the tests using conceptually and theoretically categorized variables (Bilder et al., 2002; Bleiberg et al., 2000; Langenecker et al., 2007; Rund et al., 2006 "
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    ABSTRACT: Intermediate cognitive phenotypes (ICPs) are measurable and quantifiable states that may be objectively assessed in a standardized method, and can be integrated into association studies, including genetic, biochemical, clinical, and imaging based correlates. The present study used neuropsychological measures as ICPs, with factor scores in executive functioning, attention, memory, fine motor function, and emotion processing, similar to prior work in schizophrenia. Healthy control subjects (HC, n=34) and euthymic (E, n=66), depressed (D, n=43), or hypomanic/mixed (HM, n=13) patients with bipolar disorder (BD) were assessed with neuropsychological tests. These were from eight domains consistent with previous literature; auditory memory, visual memory, processing speed with interference resolution, verbal fluency and processing speed, conceptual reasoning and set-shifting, inhibitory control, emotion processing, and fine motor dexterity. Of the eight factor scores, the HC group outperformed the E group in three (Processing Speed with Interference Resolution, Visual Memory, Fine Motor Dexterity), the D group in seven (all except Inhibitory Control), and the HM group in four (Inhibitory Control, Processing Speed with Interference Resolution, Fine Motor Dexterity, and Auditory Memory). The HM group was relatively small, thus effects of this phase of illness may have been underestimated. Effects of medication could not be fully controlled without a randomized, double-blind, placebo-controlled study. Use of the factor scores can assist in determining ICPs for BD and related disorders, and may provide more specific targets for development of new treatments. We highlight strong ICPs (Processing Speed with Interference Resolution, Visual Memory, Fine Motor Dexterity) for further study, consistent with the existing literature.
    Journal of Affective Disorders 09/2009; 122(3):285-93. DOI:10.1016/j.jad.2009.08.018 · 3.38 Impact Factor
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