Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes are noncompetitive.

Second Department of Internal Medicine, Hamamatsu Univeristy School of Medicine, Hamamatsu 431-3192, Japan.
Infection and Immunity (Impact Factor: 4.16). 06/2001; 69(5):3427-30. DOI: 10.1128/IAI.69.5.3427-3430.2001
Source: PubMed

ABSTRACT Taking advantage of the fact that plasmid DNA encoding a single cytotoxic T lymphocyte (CTL) epitope can induce CTLs, we examined the influence of T-cell responses to dominant epitopes on those to a subdominant epitope derived from Listeria monocytogenes. Our data suggest that interaction between T cells against dominant and subdominant epitopes does not operate in the generation of the hierarchy. Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity.

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