An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa.
ABSTRACT Many patients with seasonal affective disorder (SAD) have dysfunctional eating behaviors. Conversely, many women with bulimia nervosa have marked winter worsening of mood and bulimic symptoms. Controlled studies of light therapy in SAD and in bulimia nervosa have shown beneficial effects on mood and binge/purge symptoms. We explored the clinical use of light therapy in women with SAD who also had comorbid bulimia nervosa.
Twenty-two female patients diagnosed using DSM-IV criteria with both bulimia nervosa and major depressive disorder with a seasonal (winter) pattern were treated with an open design, 4-week trial of light therapy (10,000 lux fluorescent light box with an ultraviolet filter, 30 to 60 minutes per day in the early morning). Patients were assessed before and after treatment with depression scales and with binge/purge diaries.
Light therapy resulted in significant improvement in mood, with a mean 56% reduction in 29-item Hamilton Rating Scale for Depression scores following treatment (p < .001). The frequency of binges and purges per week also significantly decreased (p < .001) from baseline by a mean of 46% and 36%, respectively. Two (9%) of 22 patients became abstinent of binge/ purge episodes, compared with 10 (45%) of 22 patients who met criteria for remission of depressive symptoms. The light therapy was well tolerated by patients.
These results suggest that therapeutic effects of light therapy on mood and bulimic symptoms in patients with SAD and comorbid bulimia nervosa are sustained over at least 4 weeks. However, the low abstinence rate in bulimic symptoms indicates that light therapy may be most effectively used as an adjunctive treatment to medications and/or psychotherapy for bulimia nervosa.
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ABSTRACT: IntroductionLight therapy is a therapeutic technique based on the use of light. Its use in Psychiatry has grown over the past 30 years since the discovery of its efficacy in the treatment of seasonal affective disorder. Its mechanism of action is related to the chronobiology of circadian rhythms and to the role of melatonin in the modulation of endogenous rhythms. This article provides a critical review of the literature dealing with the use of this treatment in seasonal depression and other mood disorders (nonseasonal depression and bipolar disorder), in eating disorders, and other psychiatric syndromes.Quaderni Italiani di Psychiatria 12/2010; 29(4):134-139. DOI:10.1016/j.quip.2010.10.002
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ABSTRACT: History matching of reservoir performance is difficult due to the uncertainties associated with reservoir properties. These uncertainties include the variety of geological model and fluid model. Usually, reservoir engineer changes geological properties to match history data, but ignore the changes of fluid properties, which may have a big influence on history matching.Considering a mature field entering high water-cut stage, for many infill wells, the well productivity can be obtained by stabilized well testing, but there is a phenomenon for drawdown (DD) test where the bottom-hole pressure (BHP) may increase with time when the water-cut reaches some value. In this situation, many reservoir engineers think this phenomenon was due to the change of production rate, the change of skin factor near wellbore or the interference of multi-wells. This paper excludes the interferences of these reasons, the objective of research focus on multiphase flow and explains the phenomenon from the viewpoint of multiphase flow.It is well known that the change of pressure on late time of well testing is closed to constant in closed system or closed to zero in constant pressure system. But under transient state, steady-state or semi-steady-state conditions, if the bottom-hole pressure goes up, then the DD data may not be used for well test analysis or reservoir engineering analysis. This paper presents study results on wells producing a multiphase reservoir by numerical well test model. According to Darcy's Law, a new theoretical expression was derived in this situation, in which the derivative of bottom-hole flowing pressure is a function of integral of total mobility, which can be approximatively replaced of the average total effective mobility. Using this equation, the reason why well bottom-hole pressure increasing with time may be reasonably explained.According to the results of this study, under multiphase flow condition, the BHP increasing is due to the changing of the fluid total mobility, in this paper, it was further demonstrated that the data of this type can be used to adjust fluid model and improve history matching.Journal of Petroleum Science and Engineering 12/2010; 75(1-2):168-177. DOI:10.1016/j.petrol.2010.10.007 · 1.10 Impact Factor
Article: Eating disorders and comorbidity[Show abstract] [Hide abstract]
ABSTRACT: This review summarizes the current literature on the comorbidity of psychiatric disorders with anorexia nervosa, bulimia nervosa and binge eating disorder. The elevated prevalence of depres-sion, anxiety disorders, obsessive-compulsive disorders, substance abuse, childhood sexual abuse, and personality disorders will be reviewed. In addition, the relationship of eating disorders to body dysmorphic disorder, the menstrual cycle, pregnancy, and diabetes will be discussed.Archives of Women s Mental Health 01/2002; 4(3):67-78. DOI:10.1007/s007370200002 · 1.96 Impact Factor