[The effect of insulin-like growth factor I and insulin on intrauterine fetal growth retardation].
ABSTRACT To evaluate the role of insulin-like growth factor I (IGF-I) and insulin (Ins) in the occurrence of intrauterine fetal growth retardation (IUGR).
The study group included 17 women with IUGR, and 38 normal third trimester pregnant women were served as control. Maternal venous blood samples were collected from all cases before cesarean section. Umbilical venous blood and amniotic fluid were collected at the time of operation. The concentrations of Ins were measured by radioimmunoassay and concentrations of IGF-I were assayed by ELISA.
The maternal serum IGF-I in IUGR group (117.29 micrograms/L) was significantly lower than that in the control group (207.07 micrograms/L) (P < 0.002). The umbilical serum IGF-I in IUGR group (16.73 micrograms/L) was significantly lower than that in the control (44.89 micrograms/L) (P < 0.001). There was no significant difference of maternal serum Ins between IUGR group (12.18 mIU/L) and control group (7.13 mIU/L).
The change of IGF-I and Ins levels in maternal and umbilical serum may play an important role in the pathophysiological changes in IUGR.
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ABSTRACT: To explore the immunological regulatory mechanisms of interferon-gamma (IFN-γ) on insulin-like growth factor 1(IGF-1) and its effect on pregnancy, the dynamic expression of mRNA and cellular localization of IGF-1 protein in the early pregnant (Day 9) rats after the injection of different doses of IFN-γ, their ovaries and uterus were collected and processed by RT-PCR and immunohistochemistry. ELISA assay was also applied to investigate the effect of exogenous IFN-γ on the level of IGF-1 in the peripheral blood. The results indicate that both uterine and ovarian IGF-1 mRNAs and IGF-1 immunoreactivity were the highest in the normal saline group and the lowest in the 300IU IFN-γ group (P < 0.01). When compared with the normal saline group, the IGF-1 expression was also lower in the 100IU IFN-γ-treated group (P < 0.05). The level of IGF-1 in peripheral blood of the 300IU IFN-γ group was the lowest, which was significantly different from normal saline group (P < 0.01) and 100IU IFN-γ group (P < 0.05), respectively. The results suggest that exogenous IFN-γ might regulate pregnancy by controlling the expression of IGF-1 in the uterus and ovaries in early pregnancy.
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ABSTRACT: Breast cancer may originate in utero. We reviewed the available evidence on the association between birthweight and the risk of breast cancer. To date, 26 research papers addressing this issue have been published. The majority of studies identified a positive link between birthweight and premenopausal, but not postmenopausal, breast cancer. The relative risk estimate for breast cancer comparing women with high birthweight to women with low birthweight combining all studies including both pre- and postmenopausal breast cancer was 1.23 (95% confidence interval 1.13-1.34). The mechanisms underlying this association likely include elevated levels of growth factors that may increase the number of susceptible stem cells in the mammary gland or initiate tumors through DNA mutations. Loss of imprinting (LOI) of growth hormone genes relevant for intrauterine growth, such as insulin-like growth factor 2 (IGF2), leads to abnormally high levels of these hormones evidenced by high birthweight. LOI of IGF2 has also been found in mammary tumor tissue. The role of environmental factors that stimulate such epigenetic regulation of gene expression remains to be elucidated.International Journal of Cancer 11/2006; 119(9):2007-25. DOI:10.1002/ijc.22004 · 5.01 Impact Factor
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ABSTRACT: In der vorgelegten Arbeit wurde der Einfluss von Glucoseinfusionen auf die fetoplazentare Perfusion und das fetale Wachstum bei Patientinnen mit der Diagnose Plazentainsuffizienz untersucht. Es wurden 166 Patientinnen untersucht, 47 Frauen bekamen eine einheitliche Glucosetherapie und 27 erhielten zwei unterschiedliche Infusionsdosen im Wechsel, 75 bildeten die Kontrollgruppe, zusätzlich wurde herkömmlich therapiert. Desweiteren wurden Pat. mit Praeeklampsie und vor Therapiebeginn bestehenden pathologischen umbilikalen Dopplerwerten beleuchtet. Beurteilungskriterium waren die dopplersonografischen Parameter PI und RI der A. umbilicalis. Außerdem wurde der postpartale Zustand des Kindes verglichen. Bei Therapie ueber neun Tage kam es zur signifikanten Verbesserung der Dopplerparameter. Sowohl alternierende als auch einheitliche Glucoseinfusionstherapien verbessern die Umbilikalarterienperfusion signifikant und koennen damit das fetale Wachstum guenstig beeinflussen.