Involvement of 2p23 in pulmonary inflammatory pseudotumors.

Department of Pathology, University of Pittsburgh Medical Center-Presbyterian University Hospital, Pittsburgh, PA 15213, USA.
Human Pathlogy (Impact Factor: 2.81). 05/2001; 32(4):428-33. DOI: 10.1053/hupa.2001.23523
Source: PubMed

ABSTRACT Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified clonal chromosomal aberrations involving 2p23 in the region of the ALK gene. Using fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 and immunostaining for the ALK gene product, we studied formalin-fixed, paraffin-embedded tissues of pulmonary IP and found a subset (33%) with 2p23 aberrations. We suggest that chromosomal rearrangements and ALK immunostaining may be helpful in the diagnosis of a group of pulmonary IP and should be investigated as a potential tool for predicting their future biologic behavior. An association with anaplastic large-cell lymphoma was also observed. HUM PATHOL 32:428-433.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Fibroblastic-myofibroblastic proliferations of childhood and adolescents form a clinical and morphologic spectrum from benign reactive processes and pseudosarcomas, to fibromatoses, to various types of sarcoma. The diagnosis is challenging because of clinical and morphologic similarities, lack of specific immunohistochemical markers for different types of fibroblastic-myofibroblastic tumors, and limited molecular genetic information. Careful attention to clinical, macroscopic, and histopathologic features permits classification in most cases. This review focuses on the pathologic features of fibroblastic-myofibroblastic tumors with a predilection for children and adolescents.
    Annales de Pathologie 12/2004; 24(6):605-620. · 0.29 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Kayexalate (sodium polystyrene sulfonate), a cation exchange resin often used to treat hyperkalemia, is known to produce gastrointestinal complications in a minority of patients. These complications range from mild gastrointestinal bleeding to perforation with acute abdomen. The typical histopathologic findings include mucosal ulceration, necrosis, and the presence of polygonal basophilic refractile crystals with a "fish scale" appearance. We present a unique case of Kayexalate crystals embedded in a perihepatic inflammatory pseudotumor, developing adjacent to a colostomy site in a 62-year-old woman following Kayexalate treatment. Microscopically, the lesion demonstrated a myofibroblastic proliferation rich in histiocytes and inflammation (lymphocytes, plasma cells, and eosinophils) as well as the presence of scattered typical Kayexalate crystals. This is the first report of extraintestinal Kayexalate identification in association with an inflammatory pseudotumor.
    International Journal of Surgical Pathology 10/2013; · 0.96 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: AIM: The aim of the study was to present the largest series of colonic inflammatory myofibroblastic tumour (C-IMFT) in the literature so far and to provide a review of this condition. METHOD: A retrospective review was carried out of a consecutive series of patients diagnosed at a community-based hospital with a specialized gastro-intestinal unit with a C-IMFT between 2002 and 2011. The main outcome measures were success rate and postoperative complications. Using a set of terms we searched the databases Pub Med for articles published on C-IMFT. We reviewed the data from these studies and case reports. RESULTS: There were seven patients with a histopathologically proven C-IMFT. The patients' mean age was 39±11.3 years. Four presented with clinical features of intestinal obstruction of varying severity and three with symptoms of anaemia. Complete surgical resection with end-to-end anastomosis was performed. The gross morphology included polypoidal myxoid tumours that served as a lead point for intussusception in two cases, a whorled mass in two and a circumferential infiltrative tumour in three. Microscopically, all tumours had typical features of IMFT with a variable expression of ALK-1 and tumour-free resection margins. All patients were well, without local recurrence or metastasis at a mean follow-up of 46.8±11.9 months. CONCLUSION: Surgical resection is effective for this rare tumour which mostly behaves in a benign manner. Our review supports the need for patients to be followed up for long periods because of the possibility of metastasis or late recurrence. © 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
    Colorectal Disease 01/2013; · 2.02 Impact Factor