Microencapsulation of ibuprofen and Eudragit RS 100 by the emulsion solvent diffusion technique.
ABSTRACT The emulsion solvent diffusion was employed to prepare modified release microspheres of ibuprofen. The technique was optimised for the following processing variables: the absence/presence of baffles in the reaction vessel, agitation rate and drying time. Thereafter, the influence of various formulation factors on the microencapsulation efficiency, in vitro drug release and micromeritic properties was examined. The variables included the methacrylic polymer, Eudragit(R) RS 100, ibuprofen content and the volume of ethanol used during microencapsulation. The results obtained were then interpreted on a triangular phase diagram to map the region of microencapsulation, as well as those formulations that yielded suitable modified release ibuprofen microspheres.
- SourceAvailable from: Venkatesan Palanivel[Show abstract] [Hide abstract]
ABSTRACT: The aim of present study was to formulate and evaluate the loxoprofen loaded Sustained release microspheres by emulsion solvent evaporation technique. Ethylcellulose, a biocompatible polymer is used as the retardant material. The effects of process conditions such as drug loading, polymer type and solvent type on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their particle size and drug loading and drug release. The in-vitro release studies were carried out in phosphate buffer at pH 7.4. The prepared microspheres were white, free flowing and spherical in shape. The drug-loaded microspheres showed 71.2% of entrapment and the in-vitro release studies showed that Loxoprofen microspheres of 1:3 ratios showed better sustained effect over a period of 8 hours.Journal of basic and clinical pharmacy. 06/2011; 2(3):159-62.
- [Show abstract] [Hide abstract]
ABSTRACT: In order to evaluate the wall forming and sustained release potential of the resin of Boswellia papyrifera in diclofenac sodium microcapsules, different formulations were prepared by the emulsion solvent evaporation method at varying polymer to drug ratios. It was found that formulations with polymer to drug ratio ranging from 2:1 to 5:1 resulted in microcapsules as confirmed from optical microscopy observations. The effects of other variables such as stirring rate, temperature and volume of dispersed phase, on characteristics of microcapsules were also studied. Preliminary studies revealed that the polymer to drug ratio and stirring rate are the primary factors which affect the response variables (encapsulation efficiency and release rate). Thus, central composite design (CCD) was employed to optimize the encapsulation efficiency and release rate with respect to polymer to drug ratio and stirring rate. Accordingly, the central composite design provided an optimum region with an encapsulation efficiency of 27.24 % and release rate of 26.76 h-1/2 at 3.7:1 polymer to drug ratio and 1200 rpm stirring rate. The optimum formulation provided discrete, spherical and freely flowing microcapsules. The in vitro drug release exhibited minimum burst release with sustained release for 12 h. Kinetic study showed the optimized formulation followed Higuchi square root kinetic model with non-Fickian diffusion mechanism. FT-IR analysis indicated that there is no incompatibility between diclofenac sodium and the resin of B. papyrifera. Thus, the resin of B. papyrifera could be a potential alternative wall material for microencapsulation. Keywords: Olibanum resin, diclofenac sodium, microcapsules, central composite design, release kinetics.International Journal of Pharmacy and Pharmaceutical Sciences 12/2013; 6(1):827-837. · 1.59 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The objective of this study was to investigate the influence of emulsion processing with various homogenization treatments on the physical properties of nanoparticles. For the manufacturing of nanoparticles, by taking the emulsion-diffusion method, various coating materials, such as gum arabic, hydroxyethyl starch, polycarprolactone, paraffin wax, -carrageenan and emulsifiers like Tween60, Tween80, monoglyceride and PluronicF68, were added into the emulsion system. Furthermore, the various speeds (7,000 rpm to 10,000 rpm), and times (15 s to 60 s) of homogenization were treated during the emulsion- diffusion process. NEO II homomixer was the most effective homogenizer for making nanoparticles as 51 nm () and 26 nm (). To manufacture smaller nanoparticles, by using NEO II homomixer, 10,000 rpm of agitation speed, polycaprolactone as coating material, and PluronicF68 as an emulsifier were the optimum operating conditions and components. For the stability of nanoparticles for 7 days, of storage temperature was appropriate to maintain the particle size. From these results, the type of homogenizer, homogenization speed, homogenization time and storage temperature could affect the particle size. Moreover, type of coating materials and emulsifier also influenced the size and stability of the nanoparticles.Hangug chugsan sigpum haghoeji = Korean journal for food science of animal resources 01/2012; 32(2). · 0.25 Impact Factor