Skin diseases in children with organ transplants
ABSTRACT Skin diseases are frequent in organ transplant recipients, but studies concerning children are sparse.
We assessed skin diseases in children who had received organ transplants.
A total of 145 children referred to our dermatologic consultation were studied.
Steroid-induced striae distensae and acne occurred only in adolescents; severe cyclosporine-related side effects were more frequent in younger children. The most common findings were warts (53.8%), tinea versicolor (14.5%), herpes simplex/zoster (9.6%), molluscum contagiosum (6.9%), and impetigo contagiosum and folliculitis (6.2%). Other notable disorders included a diffuse hyperpigmentation with a "dirty" appearance of the skin, pyogenic granulomas, melanocytic nevi proliferation, and skin tags. Two of 20 further adult patients who received transplants during childhood had squamous cell carcinomas.
Children who have received organ transplants frequently present side effects of immunosuppressive drugs and infectious diseases. Most disorders are related to the age of the patients rather than to the length of immunosuppression, whereas others are favored by the reinforcement of immunosuppression. Skin cancers were not encountered, but the risk of carcinomas in early adulthood should be considered.
- SourceAvailable from: Olivier VanhooteghemAnnales de Dermatologie et de Vénéréologie 04/2008; 135(4):333-333. DOI:10.1016/j.annder.2008.02.006 · 0.67 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The number of organ transplant recipients (OTR) is growing steadily thanks to the improvements in organ preservation, transplantation surgery and immunosuppressive treatments. For the graft to function well it requires patients to be, in most cases, on lifelong immunosuppressive treatment. As a consequence, these patients have a high risk for developing various malignancies, namely those associated with viruses. Skin cancers, especially squamous cell carcinomas (SCC), account for the most frequent malignancies, affecting about 50% of patients within 20 years of transplantation. SCC tend to be multiple, may have a life-threatening course and seem to be a hallmark for developing other malignancies. Risk factors for skin carcinomas include ultraviolet light, immunosuppression, age, fair skin type, genetic factors and human papillomavirus infection. The frequency of skin carcinomas could be decreased by adequately educating patients regarding sun protection after transplantation. The incidence of Kaposi's sarcoma (KS), associated with a recently discovered virus (KS-associated herpesvirus/Human Herpes Virus 8), lymphomas, melanomas, anogenital carcinoma and some other rare tumors (such as Merkel cell carcinomas and sarcomas) is also increased in patients receiving immunosuppression, and may have an aggressive course.American Journal of Cancer 01/2002; 1(2):109-120. DOI:10.2165/00024669-200201020-00004
- Nephrology Dialysis Transplantation 06/2002; 17(5):927-8. DOI:10.1093/ndt/17.5.927 · 3.49 Impact Factor