Skin disease in children with organ transplant

CHU de Lyon - Groupement Hospitalier Edouard Herriot, Lyons, Rhône-Alpes, France
Journal of the American Academy of Dermatology (Impact Factor: 4.45). 07/2001; 44(6):932-9. DOI: 10.1067/mjd.2001.113465
Source: PubMed


Skin diseases are frequent in organ transplant recipients, but studies concerning children are sparse.
We assessed skin diseases in children who had received organ transplants.
A total of 145 children referred to our dermatologic consultation were studied.
Steroid-induced striae distensae and acne occurred only in adolescents; severe cyclosporine-related side effects were more frequent in younger children. The most common findings were warts (53.8%), tinea versicolor (14.5%), herpes simplex/zoster (9.6%), molluscum contagiosum (6.9%), and impetigo contagiosum and folliculitis (6.2%). Other notable disorders included a diffuse hyperpigmentation with a "dirty" appearance of the skin, pyogenic granulomas, melanocytic nevi proliferation, and skin tags. Two of 20 further adult patients who received transplants during childhood had squamous cell carcinomas.
Children who have received organ transplants frequently present side effects of immunosuppressive drugs and infectious diseases. Most disorders are related to the age of the patients rather than to the length of immunosuppression, whereas others are favored by the reinforcement of immunosuppression. Skin cancers were not encountered, but the risk of carcinomas in early adulthood should be considered.

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    • "The extension of MC in transplant recipients is not as well recorded as other infections.17 In a study of skin disease with 145 transplanted children, MC occurred in 6.9% of patients, being the fourth most detected infection after viral warts, pityriasis versicolor and herpes simplex / herpes zoster.21 "
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    ABSTRACT: The increasing in the number of kidney transplant recipients has favored, more frequently than before, the emergence of dermatoses and warranted their study through subsequent publications. to evaluate the frequency of dermatoses in kidney transplant recipients. kidney transplant recipients with suspected dermatoses between March 1st 2009 and June 30th 2010. 53 patients (28 males and 25 females), aged between 22 and 69 (mean age = 45 years) were evaluated. Most of them came from the cities of Ceilândia, Samambaia and São Sebastião/DF, and had already been transplanted for 5 to 10 years before (37.7%); 62.3% were recipients of living donors and 83% were prednisone-treated. The most prevalent dermatoses were of fungal (45.3%) and viral (39.6%) etiologies. Among the non-melanoma malignant neoplasms, the basal cell carcinoma prevailed (six cases), in spite of the low incidence. Concerning fungal dermatoses, 12 cases of onychomycosis, five of pityriasis versicolor and four of pityrosporum folliculitis were reported. For diagnosis, in most cases (64.2%), laboratory examinations (mycological and histopathological) were performed. cutaneous manifestations in kidney transplant recipients are generally secondary to immunosuppression. The infectious dermatoses, especially those of fungal origin, are frequently found in kidney transplant recipients and their occurrence increases progressively according to the time elapsed from the transplantation, which makes follow-up important.
    Anais brasileiros de dermatologia 06/2013; 88(3). DOI:10.1590/abd1806-4841.20131859 · 0.72 Impact Factor
    • "They have the same incidence in both sexes.[1] Histologically, ST are composed of loose collagen fibers and dilated capillaries.[2] ST have been reported to be associated with many diseases and conditions including diabetes mellitus,[3] obesity,[4] acromegaly,[5] Crohn's disease,[6] aging,[7] child abuse,[8] organ transplantation[9] and colonic polyps.[10] It was also recorded with pregnancy,[11] with human papilloma virus,[12] with increased mast cell count[13] and with increased androgen, α and β estrogen receptor levels.[14] "
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    ABSTRACT: Skin tags (ST) are papillomas commonly found in the neck, axillae of middle-aged and elderly people Insulin and insulin-like growth factor (IGF-1) levels are affected by hepatitis C virus (HCV) infection and both of them may be implicated in the etiopathogenesis of ST and acanthosis nigricans (AN) through their proliferative and differentiating properties. So, the aim of this work was to evaluate the impact of HCV infection on ST and AN through the estimation of insulin resistance and IGF-1. PARTICIPANTS WERE ARRANGED INTO FOUR GROUPS: (ST +ve / HCV +ve) 23 subjects, (ST+ / HCV -ve) 19 subjects, (HCV -ve / ST-ve) 20 subjects and (ST-ve /HCV +ve) 22 subjects. Age, ST size, color, number, AN, fasting glucose, fasting insulin, insulin resistance, IGF-1, HCV-antibodies (Ab) were recorded. The mean number of ST in Group 1 was half the number of ST in Group 2 (11.0±9.3 / 22.3±14.0) (P=0.005). The difference in insulin resistance between the same groups was non-significant (13.1±10.6 / 9.0±5.5) (P=0.441) while the difference in IGF-1 was statistically significant (218.6±46.2 /285.4±32.8) (P=0.002). The multivariate logistic regression for the variables revealed that insulin resistance is the only factor affecting the occurrence of ST (OR=1.096, P=0.023). Multivariate regression analysis for the variables showed that HCV was borderline but not a significant factor affecting the number of ST (Beta=-0.409, P=0.053). The number of patients with AN was doubled in Group 2 in comparison to Group 1 but this was non significant 3(13%) / 6(32%) (P=0.2800). HCV is associated with a significant decrease in the ST number and in the serum level of IGF-1 together with an obvious decrease in the occurrence of AN. Our results may point to the entrant effect of insulin resistance and IGF-1 in ST and AN development. The current study suggests the evaluation of IGF-1-lowering agents in the control of ST and AN especially in the females with polycystic ovary and in the prevention of the recurrence of ST after surgical removal.
    Indian Journal of Dermatology 03/2012; 57(2):102-6. DOI:10.4103/0019-5154.94275
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    • "L'immunodéficience sur lymphome [17] [18], sur chimiothérapie [19], après greffe de moelle [20] peut être responsable de la dissémination du MC. Chez l'enfant greffé, la présence de MC est estimée à près de 7 % [21] et prend l'aspect de lésion verruqueuse ou papuleuse de plus de 1 cm de diamètre. La présence de MC confiné sur des plaques de mycosis fungoïde est rapportée sous la dénomination de « lymphome molluscoïde » [22]. "

    Annales de Dermatologie et de Vénéréologie 04/2008; 135(4):333-333. DOI:10.1016/j.annder.2008.02.006 · 0.92 Impact Factor
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