Skin disease in children with organ transplant

CHU de Lyon - Groupement Hospitalier Edouard Herriot, Lyons, Rhône-Alpes, France
Journal of the American Academy of Dermatology (Impact Factor: 4.45). 07/2001; 44(6):932-9. DOI: 10.1067/mjd.2001.113465
Source: PubMed


Skin diseases are frequent in organ transplant recipients, but studies concerning children are sparse.
We assessed skin diseases in children who had received organ transplants.
A total of 145 children referred to our dermatologic consultation were studied.
Steroid-induced striae distensae and acne occurred only in adolescents; severe cyclosporine-related side effects were more frequent in younger children. The most common findings were warts (53.8%), tinea versicolor (14.5%), herpes simplex/zoster (9.6%), molluscum contagiosum (6.9%), and impetigo contagiosum and folliculitis (6.2%). Other notable disorders included a diffuse hyperpigmentation with a "dirty" appearance of the skin, pyogenic granulomas, melanocytic nevi proliferation, and skin tags. Two of 20 further adult patients who received transplants during childhood had squamous cell carcinomas.
Children who have received organ transplants frequently present side effects of immunosuppressive drugs and infectious diseases. Most disorders are related to the age of the patients rather than to the length of immunosuppression, whereas others are favored by the reinforcement of immunosuppression. Skin cancers were not encountered, but the risk of carcinomas in early adulthood should be considered.

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    • "The extension of MC in transplant recipients is not as well recorded as other infections.17 In a study of skin disease with 145 transplanted children, MC occurred in 6.9% of patients, being the fourth most detected infection after viral warts, pityriasis versicolor and herpes simplex / herpes zoster.21 "
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    • "They have the same incidence in both sexes.[1] Histologically, ST are composed of loose collagen fibers and dilated capillaries.[2] ST have been reported to be associated with many diseases and conditions including diabetes mellitus,[3] obesity,[4] acromegaly,[5] Crohn's disease,[6] aging,[7] child abuse,[8] organ transplantation[9] and colonic polyps.[10] It was also recorded with pregnancy,[11] with human papilloma virus,[12] with increased mast cell count[13] and with increased androgen, α and β estrogen receptor levels.[14] "
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    • "L'immunodéficience sur lymphome [17] [18], sur chimiothérapie [19], après greffe de moelle [20] peut être responsable de la dissémination du MC. Chez l'enfant greffé, la présence de MC est estimée à près de 7 % [21] et prend l'aspect de lésion verruqueuse ou papuleuse de plus de 1 cm de diamètre. La présence de MC confiné sur des plaques de mycosis fungoïde est rapportée sous la dénomination de « lymphome molluscoïde » [22]. "
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