Article

Dynamics of mononuclear phagocytes in lymph nodes and granulomas in chronic tuberculous inflammation.

Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Siberia, Russia.
Bulletin of Experimental Biology and Medicine (impact factor: 0.27). 03/2001; 131(2):165-8. pp.165-8
Source: PubMed

ABSTRACT Quantitative changes in mononuclear phagocytes in lymph nodes and tuberculous granulomas in patients with generalized tuberculosis suggest that accumulation of these cells in granulomas occurs due to their recruiting from bone marrow precursors, rather than from lymph nodes. Antimycobacterial therapy leads to dissociation of granulomas accompanied by accumulation of macrophages in lymph nodes. The number of granulomas decreases, but not their size and relative content of epithelioid cells remain unchanged. With due regard of the microanatomy of granulomas, epithelioid cells are regarded as the main site of mycobacterium persistence and the object of targeted drug delivery.

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Keywords

accumulation
 
bone marrow precursors
 
drug delivery
 
due regard
 
epithelioid cells
 
granulomas
 
granulomas decreases
 
lymph nodes
 
macrophages
 
main site
 
mononuclear phagocytes
 
patients
 
Quantitative changes
 
relative content
 
tuberculous granulomas
 

V A Shkurupii