Article
Hematopoietic stem cells.
Department of Hematology & Oncology, University Hospital, Innsbruck, Austria.
Biomedecine [?] Pharmacotherapy (impact factor:
2).
06/2001;
55(4):186-94.
pp.186-94
Source: PubMed
-
Citations (0)
- Cited In (3)
-
Article: Bone marrow progenitor cells and vascular endothelium: Studies on the in vivo differentiation capacity and the role of Bmx tyrosine kinase
-
Article: The BMX Tyrosine Kinase: A Signal Mediator in Hematopoietic and Endothelial/Epithelial Cells
-
Article: Clinical observation of factors in the efficacy of blood component transfusion in patients following hematopoietic stem cell transplantation.
[show abstract] [hide abstract]
ABSTRACT: Factors affecting the efficacy of platelet and red blood cell (RBC) transfusion in patients undergoing hematopoietic stem cell transplantation (HSCT) have not been studied extensively. We aimed to evaluate platelet and RBC transfusion efficacy by measuring the platelet corrected count increment and the hemoglobin increment, respectively, 24 h after transfusion in 105 patients who received HSCT. Using retrospective analysis, we studied whether factors, including gender, time of transplantation, the compatibility of ABO group between HSC donors and recipients, and autologous or allogenic transplantation, influence the efficacy of blood component transfusion. We found that the infection rate of HSCT patients positively correlated with the transfusion amount, and the length of stay in the laminar flow room was associated with transfusion. We found that platelet transfusion performed during HSCT showed significantly better efficacy than that performed before HSCT. The effect of platelet transfusion in auto-transplantation was significantly better than that in allo-transplantation. The efficacy of RBC transfusion during HSCT was significantly lower than that performed before HSCT. The efficacy of RBC transfusion in auto-transplantation was significantly higher than that in allo-transplantation. Allo-transplantation patients who received HSCs from compatible ABO groups showed significantly higher efficacy during both platelet and RBC transfusion. We conclude that the efficacy of platelet and RBC transfusions does not correlate with the gender of patients, while it significantly correlates with the time of transplantation, type of transplantation, and ABO compatibility between HSC donors and recipients. During HSCT, the infection rate of patients positively correlates with the transfusion amount of RBCs and platelets. The total volume of RBC units transfused positively correlates with the length of the patients' stay in the laminar flow room.PLoS ONE 01/2012; 7(5):e36912. · 4.09 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed.
The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual
current impact factor.
Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence
agreement may be applicable.
Keywords
adequate production
adults
blood cells
bone marrow
bone marrow aplasia
bone marrow-derived
clinical transplantation
clinical use
convenient harvest
disease-related bone marrow failure
enumeration
ex vivo expansion
Future directions
hematopoietic cytokines
hematopoietic system
identification/expansion
immature hematopoietic
non-hematopoietic tissues
peripheral blood
reconstitute
