Non-Hodgkin's lymphoma involving the gynecologic tract: A review of 88 cases
ABSTRACT Non-Hodgkin's lymphoma (NHL) involving the gynecologic tract is unusual and may cause confusion for the pathologist not familiar with its clinical and histologic features. The literature regarding this topic is also confusing, as modern NHL classification systems were not used or patients were not staged according to the Ann Arbor system in many prior reports. In addition, immunophenotypic data is not available for many cases, particularly in older studies. In the past year, there has been an interest in NHL involving the gynecologic tract and 88 cases have been collected. These cases were reviewed in the Pathology Department of M.D. Anderson Cancer Center during the past two decades, and many of these patients were treated at this hospital. In this review, these cases are reported using updated terminology and almost all cases were immunophenotyped using immunohistochemical methods or flow cytometric methods in a small subset of cases. These cases have also been segregated into two groups: 1) localized NHL, that presumably initially arose in the gynecologic tract and therefore are primary; and 2) NHL that involved the gynecologic tract as a part of systemic disease, and therefore most likely represent secondary involvement of the gynecologic tract. The differential diagnosis of NHL involving gynecologic organs is discussed.
Conference Paper: Genetic-based fuzzy adaptation[Show abstract] [Hide abstract]
ABSTRACT: A novel paradigm for adaptation in discrete event dynamic systems control is presented. In this approach a few optimal control policies are used to train an adaptation module capable of generalizing over several operating conditions. The general idea is then applied, through simulations, to an inventory system. A fuzzy adaptation module is built from a few optimal examples generated using a genetic algorithm. The fuzzy module is then capable of adapting the inventory policy achieving much better results than a static policyFuzzy Systems Proceedings, 1998. IEEE World Congress on Computational Intelligence., The 1998 IEEE International Conference on; 06/1998
- [Show abstract] [Hide abstract]
ABSTRACT: Primary (localized) non-Hodgkin's lymphoma (NHL) of the ovary is rare. We studied eight cases of primary ovarian NHL to better understand the clinicopathologic and immunophenotypic features of these tumors. The patients ranged in age from 29 to 62 years (mean 47 years). Pelvic complaints were the most common symptoms; however, three of eight neoplasms were discovered incidentally. All tumors were unilateral and Ann Arbor stage I(E). The three incidental NHL were microscopic (largest 1.2 cm), whereas the grossly evident lesions ranged from 7.5 to 20 cm (mean 13.3). Each tumor was classified according to the World Health Organization Classification as follows: diffuse large B-cell lymphoma (three cases), follicular lymphoma (two cases), Burkitt lymphoma (one case), T-cell anaplastic large cell lymphoma (one case), and precursor T-lymphoblastic lymphoma (one case). Six tumors were of B-cell lineage, and two tumors were of T-cell lineage. All three diffuse large B-cell lymphomas were positive for BCL-6, two were positive for CD10, and two were positive for BCL-2. Estrogen and progesterone receptors were negative in all NHLs assessed. Patients were treated by various combinations of surgery, chemotherapy, and radiotherapy. Clinical follow-up ranged from 1.3 to 11.7 years (mean 5.2) and all patients were alive without disease at last follow-up. We conclude that most patients with primary ovarian NHL present with symptoms attributable to an ovarian mass, but in a subset of patients ovarian NHL may be detected incidentally. With appropriate therapy, patients appear to have a favorable prognosis although follow-up is short for some patients in this study.Modern Pathology 12/2001; 14(11):1093-9. DOI:10.1038/modpathol.3880442 · 6.36 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: We present two cases of primary lymphoma of the genital tract affecting ovary and uterus. Genital lymphomas are rare, being more frequent as a secondary affection of a systemic lymphoma than primary affection. Clynical features are similar to other gynecological cancers, so it is difficult to suspect the diagnosis before surgery. Inmunohystochemical staining tecniques are often needed in order to make a differential diagnosis. The more frequent hystological type is type B, Non Hodgkin lymphoma. The staging system used is the Ann-Arbor clasification and the main prognostic factor is the extension. We review data reported in literatureProgresos de Obstetricia y Ginecología 01/2003; 46(5):227–230. DOI:10.1016/S0304-5013(03)75888-9