Article

Double-Blind, Placebo-Controlled Trial of Clonidine in Hyperactive Children With Mental Retardation

Department of Psychiatry, King George's Medical College, Lucknow (U.P.), India.
Mental Retardation 09/2001; 39(4):259-67. DOI: 10.1352/0047-6765(2001)039<0259:DBPCTO>2.0.CO;2
Source: PubMed

ABSTRACT A 12-week, double-blind, randomized, placebo-controlled trial of oral clonidine in three fixed doses (4, 6, and 8 mcg/kg/day) using a crossover design was conducted with 10 children who had hyperkinetic disorder (mean age 7.6 years +/-.54). All had comorbid mental retardation. Both parents' ratings on the Parent Symptom Questionnaire and clinicians' ratings on the Hillside Behaviour Rating Scale showed a marked dose-related response to clonidine in hyperactivity, impulsivity, and inattention. Drowsiness was a common side effect of clonidine. It wore off by the 2nd to 4th week in most cases. Thus, clonidine is a safe and effective medication in young hyperkinetic children with comorbid mental retardation.

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    • "Therefore, it is possible that clonidine improved sleep in our subjects by improvement of bruxism and its associated autonomic arousals. Clonidine has been reported to be efficacious as a monotherapy or adjunct therapy in the treatment of sleep disorders alone [30] [38], sleep disorder with comorbic ADHD [39], behavioral disorders such as ADHD [29] [40] [41], ADHD with comorbic aggression, oppositional defiant or conduct disorders [42] [43], or ADHD with tic disorder [44] [45]. Jaselskis et al. [28] reported a double-blind, placebo-controlled cross-over trial of clonidine in eight children with autism and comorbic behavioral disorders. "
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    ABSTRACT: Children with autism spectrum disorders (ASD) often exhibit sleep and behavioral disorders. Treatment of sleep disorders can be difficult in these children. Clonidine, an alpha2-adrenergic receptor agonist, has been shown to be effective in reducing impulsivity, inattention, and hyperactivity, as well as in serving as a sedative for medial procedures. An open labeled retrospective study of clonidine in treatment of insomnia, and/or hyperactivity, inattention, mood disorder, and aggressive behaviors was conducted using parent reports of sleep initiation and maintenance, as well as behaviors prior and during clonidine treatment. Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD. The side effects were largely tolerable. Further evaluation with placebo-controlled double-blind clinical trial of clonidine use in ASD will provide more insight into the clinical efficacy and safety of the medicine in ASD.
    Brain and Development 09/2008; 30(7):454-60. DOI:10.1016/j.braindev.2007.12.007 · 1.54 Impact Factor
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    • "A eficácia do metilfenidato, comparativamente ao placebo , na redução dos sintomas de TDAH em crianças com RM foi documentada em um estudo conduzido por Pearson (2003). Da mesma forma, o uso de clonidina e de antipsicóticos atípicos , especialmente risperidona, no controle de sintomas comportamentais apresentados pelos pacientes com RM-TDAH em associação, tem se mostrado eficaz (Agarwal et al., 2001; Aman et al., 2002 e 2004; Correia Filho et al., 2005). Um estudo com 45 pacientes com RM moderado e sintomas de TDAH revelou que tanto a risperidona quanto o metilfenidato se mostraram eficazes na redução dos sintomas de desatenção e/ou hiperatividade, tendo o grupo tratado com risperidona apresentado melhor resposta, tanto na escala de desatenção quanto na de hiperatividade (Correia Filho et al., 2005). "
    Jornal brasileiro de psiquiatria 01/2007; 56. DOI:10.1590/S0047-20852007000500004
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    • "A eficácia do metilfenidato, comparativamente ao placebo , na redução dos sintomas de TDAH em crianças com RM foi documentada em um estudo conduzido por Pearson (2003). Da mesma forma, o uso de clonidina e de antipsicóticos atípicos , especialmente risperidona, no controle de sintomas comportamentais apresentados pelos pacientes com RM-TDAH em associação, tem se mostrado eficaz (Agarwal et al., 2001; Aman et al., 2002 e 2004; Correia Filho et al., 2005). Um estudo com 45 pacientes com RM moderado e sintomas de TDAH revelou que tanto a risperidona quanto o metilfenidato se mostraram eficazes na redução dos sintomas de desatenção e/ou hiperatividade, tendo o grupo tratado com risperidona apresentado melhor resposta, tanto na escala de desatenção quanto na de hiperatividade (Correia Filho et al., 2005). "
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    ABSTRACT: Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent disorder among school age children. Once understood as a common and mild disorder restricted to childhood, ADHD is now recognized as an important condition because of its poor outcome and strong association with comorbidities. Pervasive disorders and cognitive deficits, as well as learning disorders, are complex conditions and their co-ocurrence with ADHD is commonly associated with marked impairments and disabilities. These patients need more attention and personalized treatment strategies. The aim of this article is to establish a discussion about these differential diagnoses, which are a challenge in clinical practice.
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