Article

Axis formation during Drosophila oogenesis

European Molecular Biology Laboratory, Meyerhofstrabetae 1, Postfach10.2209, D-69012, Heidelberg, Germany.
Current Opinion in Genetics & Development (Impact Factor: 8.57). 09/2001; 11(4):374-83. DOI: 10.1016/S0959-437X(00)00207-0
Source: PubMed

ABSTRACT Recent advances shed light on the cellular processes that cooperate during oogenesis to produce a fully patterned egg, containing all the maternal information required for embryonic development. Progress has been made in defining the early steps in oocyte specification and it has been shown that progression of oogenesis is controlled by a meiotic checkpoint and requires active maintenance of the oocyte cell fate. The function of Gurken signalling in patterning the dorsal-ventral axis later in oogenesis is better understood. Anterior-posterior patterning of the embryo requires activities of bicoid and oskar mRNAs, localised within the oocyte. A microtubule motor, Kinesin, is directly implicated in localisation of oskar mRNA to the posterior pole of the oocyte.

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    • "In Drosophila, the anterior–posterior (AP) and dorsal–ventral body axes are determined in the developing oocyte during oogenesis . Establishment of these axes depends on cytoskeletal organization and localization of several important maternal determinants at different subcellular regions of the oocyte (Riechmann and Ephrussi, 2001; van Eeden and St Johnston, 1999). For example, the transforming growth factor a homolog Gurken (Grk) plays two essential roles in these processes. "
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    Developmental Biology 11/2012; 373(2). DOI:10.1016/j.ydbio.2012.10.029 · 3.64 Impact Factor
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    • "Based on GO annotations, we found many interesting RPW genes that are involved in regulating neuron development, such as Discs large (dlg), playing important roles in synapse remodeling during metamorphosis (Liu et al., 2010), and Glass bottom boat protein (gbb), a known BMP ligand that is important for motoneuron development(James & Broihier, 2011). We identified genes involved in dorso-ventral axis formation (Riechmann & Ephrussi, 2001), such as egfr, sos, and piwi. Other interesting genes are juvenile hormone (JH) and ecdysone, the two most important hormones regulating insect development (Andres et al., 1993; Robbins et al., 1968; Grieneisen, 1994), as well as chitin deacetylase genes, playing critical role in modifying extracellular chitin in both peritrophic membrane and cuticle during morphogenesis and molting (Dixit et al., 2008). "
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    Insect Science 07/2012; 20(6). DOI:10.1111/j.1744-7917.2012.01561.x · 1.51 Impact Factor
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    • "Two previous studies have shown that the c-TuRC components Dgrip75 and Dgrip128 (as well as ctubulin 37C) are required to localise bicoid (bcd) mRNA to the anterior of the oocytes from stage 10b/11 onwards (Schnorrer et al., 2002; Vogt et al., 2006). The correct localisation of bcd mRNA is required to help pattern the anterior-posterior axis of the Drosophila embryo (Riechmann and Ephrussi, 2001), and it has been suggested that the c-TuRC nucleates a specific subset of MTs (that cannot be nucleated by the c-TuSC) that are required for proper bcd localisation. We therefore examined whether Dgp71WD was also required for the proper localisation of bcd. "
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