Indole alkaloids from the seeds of Centaurea cyanus (Asteraceae)

Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom
Phytochemistry (Impact Factor: 3.35). 09/2001; 57(8):1273-6. DOI: 10.1016/S0031-9422(01)00084-X
Source: PubMed

ABSTRACT Preparative RP-HPLC analysis of a methanol extract of the seeds of Centaurea cyanus afforded four indole alkaloids: moschamine, cis-moschamine, centcyamine and cis-centcyamine, the latter two being new natural products. Structures of these compounds were elucidated by comprehensive spectroscopic analyses. General toxicity of the isolates was determined by Brine Shrimp Lethality bioassay.

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    ABSTRACT: Essential oil composition of Centaurea kilaea flowers, stems and C. cuneifolia flowers were investigated by GC, GC/MS. Flowers and stems of C. kilaea afforded very low essential oil yield <0.01% (v/w). Nineteen and twenty compounds were identified in the flower and stem oils which represent 59.5% and 77.6% of the C. kilaea oil respectively. The main components of the C. kilaea flower oil were hexadecanoic acid 26.2%, tetradecanoic acid 18.1%, β-Eudesmol 3.3% and decanoic acid 3.1%. The stem oil contains hexadecanoic acid 55.5% and β-Eudesmol 3.2%. Flowers of C. cuneifolia afforded very low essential oil yield <0.01% (v/w). Twenty five compounds were identified in the flower oil of C. cuneifolia which represent 69.92% of the oil. The main components of this oil include hexadecanoic acid 32.9%, tetradecanoic acid 14.4%, heptacosane 6.1% and nonacosane 4.3%. Essential oils obtained from both species have saturated fatty acids and alkanes as the major components, but both oils also contain minor amounts of sesquiterpenes.
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