Cystic neoplasms of the pancreas - Benign to malignant epithelial neoplasms
ABSTRACT Clinical presentation and state-of-the-art imaging permit the differentiation of most cystic pancreatic neoplasms not only from other cystic pancreatic disorders but also from one another. The differentiation of serous cystic lesions from the mucinous neoplasms (cystadenoma or carcinoma and IPMT) is crucial because of the radically different biological characteristics of these two neoplasms. Although mucinous cystic neoplasms should be resected because of their premalignant or overtly malignant tendency, most patients with serous neoplasms require no operative intervention unless they are symptomatic. IPMT is best treated by a total pancreatectomy, although lesser subtotal resections should be strongly considered depending on patient age, medical comorbidity, and psychosocial situations.
- SourceAvailable from: Shailesh Shrikhande
Article: Cystic tumours of the pancreas.[Show abstract] [Hide abstract]
ABSTRACT: Pancreatic carcinoma accounts for the most dismal survival among all malignancies with 5-year survival rates approaching 5%. The reason for this, besides the inherent biologic nature of the disease, is the fact that the patients tend to present late in the disease. We present a review of the current published data on cystic neoplasms of the pancreas, which though rare, constitute an important subgroup of pancreatic neoplasms that have a better prognosis and are potentially curable lesions.HPB 02/2007; 9(4):259-66. DOI:10.1080/13651820701435287 · 2.05 Impact Factor
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ABSTRACT: Background : Mucin producing cystic neoplasms, such as mucinous cystic tumor (MCT) and intraductal papillary mucinous tumor (IPMT) of the pancreas, are uncommon but become increas- ing in their incidences. The pathologic classification and biologic potential of these neoplasms remain the subject of controversy. Methods : The Gastrointestinal Pathology Study Group of the Korean Society of Pathologists analyzed the clinicopathologic characteristics of 85 cases of MCT and 72 cases of IPMT and examined the expression patterns of p53, CEA and MUC1. Results : IPMT was located largely in the head, and showed connection with the main pan- creatic duct (MPD, 68.1%), no ovarian-like stroma (0/72), and presence of intervening intra- tumoral normal or atrophic parenchyma. On the other hand, MCT was located largely in the tail (73%), and showed common ovarian-like stroma (66/80), rare connection with the MPD (7/85) and no intervening pancreatic parenchyma. CEA and p53 immunoexpressions were significantly increased from adenoma through borderline to carcinoma, but MUC 1 was expressed only in the invasive carcinoma among cases of MCT and IPMT. Conclusions : The tumor location, ovarian-like stroma, connection with the MPD and intratumoral intervening nonneo- plastic tissue were helpful in the differential diagnosis between IPMT and MCT. CEA and p53 expressions can be indicators of malignancy, while MUC 1 expression can indicate invasion.
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ABSTRACT: Splenic artery aneurysm was first described by Beaussier in 1770, and the first successful treatment was reported by McLeod in 1940. The splenic artery aneurysm is considered the most common splanchnic site for aneurysm formation, affecting 46 to 60% of patients with visceral aneurysms. Most patients are asymptomatic, and splenic artery aneu- rysm is often found during imaging investigation of other abdominal diseases. We describe an unusual case of a 31-year-old female patient with a large splenic artery aneurysm originating from the superior mesenteric artery.Jornal Vascular Brasileiro 01/2009; 8(2). DOI:10.1590/S1677-54492009000200013