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    ABSTRACT: Introduction. – Natural killer cells are cytotoxic lymphocytes of innate immunity. These last ten years our knowledge about the mechanisms that regulates NK cell function has greatly improved. Our purpose is to present a review of these new acquisitions and their potential implications in human disease.Current knowledge and key points. – NK cell function is regulated by a repertoire of NK cell receptors and is diversified by recognition of MHC class I by a multigenic and mutiallelic family of NK receptors. Analysis of NK cell repertoire has been used to investigate features that characterize NK cells in pathological situations. Apart from their direct cytotoxic potential to eliminate target cells, recently identification of mechanisms that control NK cell mediated cytokine production and cross talk with dendritic cells emphasize the role of NK cells in the regulation of acquired immune response.Future prospects and projects. – These findings have lead to a better knowledge of the importance of the NK cells in several human diseases. It has been shown that NK cells are actors of the immunosurveillance of tumoral and infectious challenges. Allo or auto reactivity of the NK cell compartment have also been suggested in autoimmune diseases, infertility or foetal loss and transplantation. Ongoing research on NK cells in the fields of human diseases is increasing and will clarify the utility of the evaluation of the NK cell compartment and their receptors in clinical practice.
    La Revue de Médecine Interne 06/2006; 27(6):465-472. DOI:10.1016/j.revmed.2005.10.022 · 1.32 Impact Factor
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    ABSTRACT: The Proceedings of the 7th Human Leukocyte Differen- tiation Antigen (HLDA) Workshop are about to be pub- lished, detailing more than 80 new CD specificities. The next Workshop, planned for 2004, will continue this process, and a number of candidate CD molecules in the literature, identified by antibody production or gene cloning, are listed in this update. The tradition of HLDA Workshops The process of categorizing the antigenic molecules and epitopes associated with human white cells, via the collaborative study of monoclonal antibodies, dates back to the early 1980s, when the first HLDA Workshop was held in Paris, France. This initial meet- ing listed only fifteen agreed molecular entities, but it created an internationally agreed basis for the nomenclature of leukocyte molecules (the CD scheme), and also provided a forum for report- ing studies on their function and practical relevance. A further six HLDA meetings have been held since the first Paris meeting. The most recent of these ("HLDA7") took place in 2000 in Harrogate, U.K., and the proceedings of the meeting will be published this year (Leucocyte Typing VII, Oxford University Press). The aims and approaches of the 7th HLDA Workshop The limitations of "blind" antibody screening