Good correlation between gated single photon emission computed myocardial tomography and contrast ventriculography in the assessment of global and regional left ventricular function.

Department of Cardiology, Leiden University Medical Center, The Netherlands.
International Journal of Cardiac Imaging 12/2000; 16(6):447-53. DOI: 10.1023/A:1010611412958
Source: PubMed

ABSTRACT The purpose of this study was to determine the reliability of the measured left ventricular ejection fraction (LVEF) and wall motion analysis by the recently introduced quantitative electrocardiographically (ECG)-gated myocardial perfusion single-photon emission computed myocardial tomography technique (gated SPECT) (QGS).
We compared technetium-99 m tetrofosmin gated SPECT imaging and contrast ventriculography in the assessment of global and regional left ventricular function in 74 patients with undiagnosed chest pain of whom 27 sustained a previous myocardial infarction.
Linear regression analysis demonstrated that gated SPECT determined LVEF correlated well with LVEF determined from contrast ventriculography (y = 0.95x + 1.9, r2 = 0.84, p < 0.0001). Bland-Altman plot analysis showed no systematic difference between the two sets of values derived from the two imaging approaches over a wide range of LVEF values. Exact agreement of segmental wall motion scores was 460 of 518 (89%) segments with a kappa value of 0.76 (p < 0.0001).
We conclude that gated SPECT imaging is an accurate and reliable clinical tool to accurately measure global and regional left ventricular function.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Mesoporous titania–alumina ceramics are interesting as catalysts and catalyst supports. Monolithic wet-gels of 0.2TiO2–0.8Al2O3, prepared by hydrolysis of metal alkoxides in alcoholic solutions, were dried at 90°C (xerogel), immersed into a surfactant solution before drying (surfactant-modified gel), or the solvent in wet gels was supercritically extracted in one step from CO2 at 60°C and 24Mpa for 2h (aerogel). Thermal evolution of the microstructure of the gels was evaluated by thermal analyses (TG-DTA), N2 adsorption, scanning electron microscopy, and X-ray diffraction. After calcination at 500°C, the specific surface area of the gels was >400m2g−1. The average pore radius for the supercritically extracted titania–alumina gel, about 8nm (∼50% of that for alumina aerogels), was 2–4 times larger than that of the surfactant-modified gels and of the xerogel. The specific surface area of the surfactant-modified gels and of the supercritically extracted gels was more than 150m2g−1 after calcination at 800°C. The pore size and pore volume of these gels minimally decreased after calcination at 800°C, while those values of the xerogel markedly decreased. The thermal stability of the microstructure of mesoporous titania–alumina is improved by surfactant immersion or supercritical extraction.
    Journal of Non-Crystalline Solids 01/2004; 350:271-276. · 1.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: All previous validation studies of quantitative gated single-photon emission tomography (QGS) have examined relatively few patients, and the accuracy of QGS thus remains uncertain. We performed a meta-analysis of data from 301 participants in ten studies that compared QGS using technetium-99m-labelled tracers with contrast left ventriculography (LVG), and from 112 participants in six studies that compared QGS with magnetic resonance imaging (MRI). Linear regression and Bland-Altman analyses were used to evaluate pooled data from individuals across the studies. The correlation between QGS and LVG for end-diastolic volume (EDV) (r=0.81, SEE=27 ml), end-systolic volume (ESV) (r=0.83, SEE=18 ml) and ejection fraction (EF) (r=0.79, SEE=8.3%) was good, as was that between QGS and MRI for EDV (r=0.87, SEE=34 ml), ESV (r=0.89, SEE=27 ml) and EF (r=0.88, SEE=7.2%). However, Bland-Altman plots indicated that LVG minus QGS differences for EDV generated a systematic and random error of 32+/-58 ml (mean+/-2SD), and that MRI minus QGS generated an error of 13+/-73 ml. In the subgroup of patients in whom ECG gating was set at eight intervals, QGS significantly underestimated EF by 7.6%+/-17.4% (mean+/-2SD) compared with LVG and by 6.3%+/-14.6% compared with MRI; no such underestimation was observed in the subgroup in whom ECG gating was set at 16 intervals. We conclude that in patients with ECG gating set at eight intervals, QGS systematically underestimates LV volumes and EF compared with both LVG and MRI. Since QGS also shows considerable variations around the systematic deviations, there remains uncertainty over whether an individual value determined with QGS approximates the true LV volumes and EF.
    European journal of nuclear medicine and molecular imaging 07/2003; 30(6):851-8. · 5.11 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hyperbranched poly(urea-urethane)-grafted multi-walled carbon nanotubes (HPU-MWCNTs) were incorporated in a polyurethane (PU) matrix based on poly(ethylene oxide-tetrahydrofuran) and aliphatic polyisocyanate resin as curing agent. The 9–12nm thick HPU shell formed on the MWCNTs improved the dispersion of MWCNTs and enhanced the interfacial adhesion between the PU matrix and MWCNTs, leading to improvements in storage modulus and Tg of the composites and enhancement of the thermal stability of PU. Thus, composites with 0.5–1wt% MWCNTs increased the thermal conductivity by about 60–70% when compared to, and retained the high electrical resistivity of, neat PU.
    Composites Part B-engineering - COMPOS PART B-ENG. 01/2011; 42(8):2111-2116.