Article

Prevention of further cyclophosphamide induced hemorrhagic cystitis by hyperbaric oxygen and mesna in guinea pigs.

Departments of Physiology and Pathology, Gülhane Military Medical Academy, Etlik, Ankara, Turkey.
The Journal of Urology (impact factor: 3.75). 10/2001; 166(3):1119-23. pp.1119-23
Source: PubMed

ABSTRACT Hyperbaric oxygen therapy and mesna have been successfully used for hemorrhagic cystitis. We defined the protective effects of hyperbaric oxygen and mesna in further cyclophosphamide induced hemorrhagic cystitis in guinea pigs.
A total of 48 male guinea pigs were divided into 6 groups. All groups received 2 doses of 68.1 mg./kg. cyclophosphamide intraperitoneally at the same time intervals but group 1 served as controls. Group 2 received cyclophosphamide only, group 3 received hyperbaric oxygen treatment (2.8 ATA for 90 minutes twice daily) before and the day after further cyclophosphamide, group 4 received 21.5 mg./kg. mesna intraperitoneally only with further cyclophosphamide, group 5 received hyperbaric oxygen and mesna with further cyclophosphamide, and group 6 received hyperbaric oxygen before initial cyclophosphamide, between the 2 doses and after the further dose of cyclophosphamide, and mesna on the days of cyclophosphamide.
Although mesna alone provided protection against cyclophosphamide induced cystitis in animal bladders, there was also significant damage compared with controls. When the uroprotective efficacy of mesna was supported with hyperbaric oxygen, bladder protection was promoted since mean histological scores and hematuria levels in this group did not differ from those in controls.
According to this animal study using hyperbaric oxygen as adjuvant therapy in humans may be a better tool than mesna alone for the prophylaxis and treatment of cyclophosphamide induced hemorrhagic cystitis.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

2 doses
 
21.5 mg./kg. mesna intraperitoneally
 
48 male guinea pigs
 
68.1 mg./kg. cyclophosphamide intraperitoneally
 
90 minutes
 
adjuvant therapy
 
animal study
 
bladder protection
 
cyclophosphamide induced cystitis
 
cyclophosphamide induced hemorrhagic cystitis
 
group 3
 
group 5
 
group 6
 
guinea pigs
 
hematuria levels
 
hemorrhagic cystitis
 
hyperbaric oxygen
 
Hyperbaric oxygen therapy
 
hyperbaric oxygen treatment
 
initial cyclophosphamide
 

A Korkmaz