Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.

Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294-3360, USA.
Anticancer research (Impact Factor: 1.87). 21(3B):1691-5.
Source: PubMed

ABSTRACT The expression of retinoid receptors is altered during the development of several types of cancer. In the present study, we determined the influence of high dietary concentrations of 4-hydroxyphenylretinamide (4-HPR) and 13-cis-retinoic acid (13-cis-RA) on RAR-beta mRNA expression in female mice. Expression of liver and lung RAR-beta RNA increased with increasing levels of dietary retinoid (both 4-HPR and 13-cis RA). Bladder RAR-beta mRNA levels, however, were significantly decreased in mice fed 13-cis RA or 4-HPR. These results suggest that feeding high levels of retinoids to mice results in tissue-specific elfects on expression of RAR-beta mRNA.


Gary Johanning