Article

[The excitatory effects of histamine on cerebellar cortical Purkinje cells in the rat].

Department of Biological Science and Technology, Nanjing University, Nanjing 210093.
Sheng li xue bao: [Acta physiologica Sinica] 05/1999; 51(2):219-23. pp.219-23
Source: PubMed

ABSTRACT The effects of histamine on Purkinje cells (PCs) in lobule X of cerebellar cortex were investigated in rat cerebellar slices. Histamine elicited PCs' responses predominately excitatory (94.4%, 51/54), only few inhibitory (5.6%, 3/54). The excitatory response could not be abolished by perfusing the slices with low Ca2+/high Mg2+ medium. The excitatory response of PCs to histamine could be blocked by histamine H2 receptor antagonist ranitidine, but not by H1 receptor antagonist triprolidine readily. These results suggest that histamine exerts an excitatory effect on the PCs via H2 receptors. Presumably, hypothalamo-cerebellar histaminergic fibers participate in the regulation of somatic and non-somatic functions of the cerebellum.

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    [show abstract] [hide abstract]
    ABSTRACT: Although a number of neuromodulators influence the cerebellar circuitry, their functions remain largely unknown. By reviewing and combining results from data-driven and theory-driven studies, we attempt to provide an integrated systems view of cerebellar neuromodulation. First, we review the short- and long-term effects of neuromodulators on the cerebellar circuitry. Second, we review recent theories of the cerebellum and show that a number of modulatory signals are needed for powerful cerebellar learning and control. Finally, we attempt to match each theoretically derived modulatory signal with a specific neuromodulator. In particular, we propose that serotonin controls the 'responsibility' of each cerebellar unit (or microcomplex) in cerebellar learning and control; norepinephrine gates unsupervised learning in the cerebellar cortex; dopamine enhances goal-oriented cerebellar learning; and, finally, acetylcholine controls the speed of supervised learning in Purkinje cells.
    Brain Research Reviews 04/2004; 44(2-3):103-16. · 10.34 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

cerebellum
 
excitatory effect
 
excitatory response
 
H1 receptor antagonist triprolidine
 
histamine
 
Histamine elicited PCs' responses predominately excitatory
 
histamine exerts
 
histamine H2 receptor antagonist ranitidine
 
hypothalamo-cerebellar histaminergic fibers
 
low Ca2+/high Mg2+ medium
 
PCs
 
Purkinje cells
 
rat cerebellar slices
 
slices
 

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