Article

HLA class II alleles associated with infection by HPV16 in cervical cancer in situ.

Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden.
International Journal of Cancer (impact factor: 5.44). 10/2001; 93(6):817-22. pp.817-22
Source: PubMed

ABSTRACT HLA class II alleles have been associated with an increased risk of developing cervical cancer through infection with oncogenic forms of human papilloma virus (HPV). We have examined the association of variation at the DRB1 and DQB1 loci with HPV16 infection and risk of development of cervical cancer by analysis of 440 cases diagnosed with cervical cancer in situ and 476 age-matched controls in a retrospective case-control study. The infection history of a woman was studied by analysis of cervical smears taken at multiple times during a period of up to 27 years (1969-95). The frequency of a number of alleles are either increased (DRB1*0801, DRB1*1501, DQB1*0402 and DQB1*0602) or decreased (DRB1*0101, DRB1*1301, DQB1*0501 and DQB1*0603) in the cancer patients compared to the controls. After correction for multiple testing, only the DQB1*0602 and the DRB1*1501 alleles remain associated with cancer and only in HPV16-infected patients (DQB1*0602: 102/264 (39%) vs. 130/476 (28%), p = 0.028 and DRB1*1501: 104/259 (40%) vs. 132/469 (28%), p = 0.027). These alleles are associated primarily with infection by HPV and only indirectly affect the risk of developing cervical cancer in situ. To study the impact of these alleles on persistence of infection, women with short-term infections were compared to those with long-term infections. Carriers of DQB1*0602 and DRB1*1501 were more frequent in the group with long-term HPV infections, indicating that these class II alleles contribute to the inability to clear an HPV infection.

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Keywords

476 age-matched controls
 
cancer patients
 
cervical cancer
 
cervical smears
 
class II alleles
 
DQB1 loci
 
DRB1
 
HLA class II alleles
 
HPV infection
 
HPV16 infection
 
HPV16-infected patients
 
human papilloma virus
 
increased risk
 
infection history
 
long-term HPV infections
 
long-term infections
 
multiple testing
 
oncogenic forms
 
retrospective case-control study
 
short-term infections
 

A H Beskow