GRR: Graphical Representation of Relationship Errors

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7RZ, UK.
Bioinformatics (Impact Factor: 4.98). 09/2001; 17(8):742-3. DOI: 10.1093/bioinformatics/17.8.742
Source: PubMed


A graphical tool for verifying assumed relationships between individuals in genetic studies is described. GRR can detect many common errors using genotypes from many markers. AVAILABILITY: GRR is available at

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    • "The class 2 isoform, which has no N-terminal domain, is also present in the human inner ear (Liang et al., 1999). Myosin XVa plays a crucial role in the graded elongation of stereocilia (Abecasis et al., 2001; Belyantseva et al., 2003; Krendel and Mooseker, 2005) and actin-organization in inner ear hair cells (Berg et al., 2001; Wang et al., 1998), which are vital for sound transduction. Myosin XVa is therefore an essential component of normal auditory function. "
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    • "We verified sample genders by counting heterozygous SNPs on the X chromosome. Relationship errors were evaluated with the help of the program Graphical Relationship Representation (Abecasis et al. 2001). The program PedCheck was applied to detect Mendelian errors (O'Connell and Weeks 1998) and data for SNPs with such errors were removed from the data set. "
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    • "The genotype data included ∼2.3 million SNPs from the Illumina Omni chip. Quality control was performed before imputation by checking pedigree relationships using GRR (Abecasis et al., 2001) and Loki (Heath, 1997) approaches. Single-nucleotide polymorphism (SNPs) were eliminated if presented Mendelian errors, coded allele frequency <1% or >99%, deviations from Hardy-Weinberg equilibrium (p < 1.0 × 10 −6 ), and/or low call rate (98%). "
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